Oligomerization of acidic fibroblast growth factor is not a prerequisite for its cell proliferation activity

Protein Science

Volumn 11, Issue 5, 2002, Pages 1050-1061

  Arunkumar, Alphonse I ^a,b,c,d,e   Kumar, Thallampuranam Krishnaswamy S ^a,b,c,d,e   Kathir, Karuppanan Muthusamy ^a,b,c,d,e   Srisailam, Sampath ^a,b,c,d,e   Wang, Han Min ^a,b,c,d,e   Leena, Philominathan Sagaya Theresa ^a,b,c,d,e   Chi, Ya Hui ^a,b,c,d,e   Chen, Ho Chz ^a,b,c,d,e   Wu, Chieh Hsi ^a,b,c,d,e   Wu, Rong Tsun ^a,b,c,d,e   Chang, Gu Gang ^a,b,c,d,e   Chiu, Ing Ming ^a,b,c,d,e   Yu, Chin ^a,b,c,d,e  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

barrel; Heparin binding; nFGF 1; Oligomerization; Receptor; Stability

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARIN; HEPARIN DERIVATIVE; PROTEOHEPARAN SULFATE; SUCRALFATE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; LIGAND BINDING; MOLECULAR INTERACTION; NEWT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR UPREGULATION; SEDIMENTATION; THERMODYNAMICS;

ANIMALS; BINDING SITES; CHROMATOGRAPHY; FIBROBLAST GROWTH FACTOR 1; MITOGENS; NOTOPHTHALMUS VIRIDESCENS; SUCROSE;

ANIMALIA; NOTOPHTHALMUS; NOTOPHTHALMUS VIRIDESCENS; SALAMANDRIDAE;

EID: 0036227885     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.2270102     Document Type: Article

References (61)

1. The FGF family of growth factors and oncogenes
2. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
3. Ligand-induced transphosphorylation between different FGF receptors
4. Biological roles of fibroblast growth factor-2
5. X-ray crystal structure of human acidic fibroblast growth factor
6. Oligomeric self-association of basic fibroblast growth factor in the absence of heparin-like glycosaminoglycans
7. Fibroblast growth factor-2 stimulation of p42/44 MAPK phosphorylation and 1KB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts
8. Structure of a heparin-linked biologically active dimer of fibroblast growth factor
9. Heparin structure and interactions with basic fibroblast growth factor
10. Diversity does make a difference: Fibroblast growth factor-heparin interactions
11. Potentiation and inhibition of bFGF binding by heparin: A model for regulation of cellular response
12. Basic fibroblast factor binds its receptors is internalized and stimulates DNA synthesis in Balb/C3T3 cells in the absence of heparan sulfate
13. Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair
14. Fibroblast growth factor prototype release and fibroblast growth factor receptor signaling
15. 2O in protein NMR. Application to sensitivity enhancement and NOE measurements
16. Build up rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: Implications for studies of protein conformation
17. Main-chain dynamics of cardiotoxin 11 from Taiwan cobra (Naja naja atra) as studied by carbon-13 NMR at natural abundance: Delineation of the role of functionally important residues
18. Bio-specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesion
19. Nature of the interaction of heparin with acidic fibroblast growth factor
20. Improved solvent suppression in one- and two-dimensional NMR spectra by Convolution Time-Domain data
21. Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins
22. 15N-labeled proteins
23. Receptor specificity of the fibroblast growth factor family
24. Modified spin-echo method for measuring nuclear spin relaxation times
25. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
26. Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implementations for mechanisms of bFGF release from pericellular matrix
27. Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor
28. Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide
29. FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
30. Fibroblast growth factors
31. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides
32. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
33. Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization
34. Amphibian FGF-1 is structurally and functionally similar to but antigenically distinguishable from its mammalian counterpart
35. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
36. Structural basis for FGF receptor dimerization and activation
37. Cloning and interspecies comparisons of three newt (Notophthalmus viridescens) fibroblast growth factor receptor sequences
38. Vincristine-induced self-association of calf brain tubulin
39. Criteria for distinguishing self-associations in velocity sedimentation
40. 1H NMR spectra of proteins via double quantum filtering
41. Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding
42. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation
43. Identification and characterization of an equilibrium intermediate in the unfolding pathway of an all beta-barrel protein
44. Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?
45. Crystal structure of a ternary FGF-FGFR heparin complex reveals a dual role for heparin in FGFR binding and dimerization
46. The S130K fibroblast growth factor-1 mutant induces heparin independent proliferation and is resistant to thrombin degradation in fibrin glue
47. Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan
48. Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis
49. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
50. Structural interactions of fibroblast growth factor receptor with its ligands
51. The mode of action of sucralfate: The 1 × 1 × 1 mechanism of action
52. Fibroblast growth factors I and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans
53. Sucralfate and soluble sucrose octasulfate bind and stabilize acidic fibroblast growth factor
54. New insights into heparin-induced FGF oligomerization
55. 15N chemical shift referencing in biomolecular NMR
56. Analysis of putative heparin-binding domains of fibroblast growth factor-2 using site-directed mutagenesis and peptide analogues
57. The cysteine-free fibroblast growth factor 9 mutant induces heparin-independent proliferation of endothelial cells and smooth muscle cells
58. Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor
59. Three-dimensional structures of acidic and basic fibroblast growth factors