The cysteine-free fibroblast growth factor 1 mutant induces heparin- independent proliferation of endothelial cells and smooth muscle cells

Journal of Surgical Research

Volumn 92, Issue 2, 2000, Pages 255-260

  Xue, Lian ^a   Shireman, Paula K ^a   Hampton, Brian ^b   Burgess, Wilson H ^b,c   Greisler, Howard P ^a,c  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b HOLLAND LABORATORY   (United States)

^c HINES VA HOSPITAL   (United States)

Author keywords

Endothelial cells; Fibrin glue; Fibroblast growth factor 1; Smooth muscle cells; Thrombin

Indexed keywords

CYSTEINE; DODECYL SULFATE SODIUM; FIBROBLAST GROWTH FACTOR 1; HEPARIN; SERINE; THROMBIN; THYMIDINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; MITOGENESIS; MOLECULAR STABILITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SMOOTH MUSCLE FIBER;

EID: 0033859223     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2000.5945     Document Type: Article

References (21)

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7. Selective stimulation of endothelial cell proliferation with inhibition of smooth muscle cell proliferation by fibroblast growth factor-1 plus heparin delivered from fibrin glue suspensions
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9. Disulfide bonds are neither required, present, nor compatible with full activity of human recombinant acidic fibroblast growth factor
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11. Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor
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21. The S130K fibroblast growth factor-1 mutant induces heparin- independent proliferation and is resistant to thrombin degradation in fibrin glue