Immunoreactivity patterns of CD31 and CD68 in 28 cases of Kaposi's sarcoma: Evidence supporting endothelial differentiation in the spindle cell component

Applied Immunohistochemistry and Molecular Morphology

Volumn 5, Issue 3, 1997, Pages 173-178

  Hoerl, Howard D ^a   Goldblum, John R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

CD31; CD68; Immunohistochemistry; Kaposi's sarcoma; Vascular differentiation

Indexed keywords

CD28 ANTIGEN; CD31 ANTIGEN; CD68 ANTIGEN;

ADULT; AGED; ANGIOGENESIS; ANTIGEN DETECTION; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; MALE; PRIORITY JOURNAL; TUMOR LOCALIZATION;

EID: 0030733159     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: 10.1097/00022744-199709000-00005     Document Type: Article

References (46)

1. Kaposi M. Idiopathisches multiples pigmentsarkom der haut. Arch Dermatol Syph 1872;4:265.
2. Rutgers JL, Wieczorek R, Bonetti F, et al. The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Am J Pathol 1986;122:493-9.
3. Jones RR, Spaull J, Spry C, Jones EW. Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS). J Pathol 1986;39:742-9.
4. Beckstead JH, Wood GS, Fletcher V. Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Am J Pathol 1985; 119:294-300.
5. Harrison AC, Kahn LB. Myogenic cells in Kaposi's sarcoma: an ultrastructural study. J Pathol 1978;124:157-66.
6. Reynolds WA, Winkelman RK, Soule EH. Kaposi's sarcoma: a clinicopathologic study with particular reference to its relationship to the reticuloendothelial system. Medicine 1965;44:419-43.
7. Nickoloff BJ, Griffiths CEM. The spindle-shaped cells in cutaneous Kaposi's sarcoma: histologic simulators include factor XIIIa dermal dendrocytes. Am J Pathol 1989;135:793-800.
8. Ordonez NG, Batsakis JG. Comparison of Ulex europaeus I lectin and factor VIII-related antigen in vascular lesions. Arch Pathol Lab Med 1984;108:129-32.
9. Ramani P, Bradley NJ, Fletcher CDM. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology 1990;17:237-42.
10. Bergdorf WHC, Mukai K, Rosai J. Immunohistochemical identification of factor VIII-related antigen in endothelial cells and cutaneous lesions of alleged vascular nature. Am J Clin Pathol 1981; 75:167-71.
11. Traweek ST, Kandalaft PL, Mehta P, Battifora H. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Am J Clin Pathol 1991;96:25-31.
12. Aziza J, Mazerolles C, Selves J, et al. Comparison of the reactivities of monoclonal antibodies QBEND/10 (CD34) and BNH-9 in vascular tumors. Appl Immunohistochem 1993;1:51-7.
13. Nickoloff BJ. The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi's sarcoma. Arch Dermatol 1991;127:523-29.
14. Kanitakis J, Narvaez D, Claudy A. Expression of the CD34 antigen distinguishes Kaposi's sarcoma from pseudo-Kaposi's sarcoma (acroangiodermatitis). Br J Dermatol 1996;133:44-6.
15. DeYoung BR, Wick MR, Fitzgibbon JF, Sirgi KE, Swanson PE. CD31: An immunospecific marker for endothelial differentiation in human neoplasms. Appl Immunohistochem 1993;1:97-100.
16. Kuzu I, Bicknell R, Harris AL, Jones M, Gatter KC, Mason DY. Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumors. J Clin Pathol 1992;45:143-8.
17. Uccini S, Luigi P, Monardo F, et al. Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells. J Pathol 1994;173:23-31.
18. Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC, Mason DY. JC70: A new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 1990;43:752-7.
19. Russell Jones R, Orchard G, Zelger B, Wilson Jones E. Immunostaining for CD31 and CD34 in Kaposi's sarcoma. J Clin Pathol 1995;48:1011-6.
20. Pulsord KAF, Rigney EM, Micklem KF, et al. KP1: A new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol 1989; 42:414-21.
21. Weiss LM, Arber DA, Chang KL. CD68: A review. Appl Immunohistochem 1994;2:2-8.
22. Ralfkiaer E, Delsol G, O'Connor NTJ, et al. Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study. J Pathol 1990;160:9-17.
23. Milchgrub S, Kamel OW, Wiley E, Vuitch F, Cleary ML, Warnke RA. Malignant histiocytic neoplasms of the small intestine. Am J Surg Pathol 1992;16:11-20.
24. Weiss SW. World Health Organization International histological classifications of tumors: Histological typing of soft tissue tumors. Berlin: Springer-Verlag, 1994.
25. Costa J, Rabson AS. Generalized Kaposi's sarcoma is not a neoplasm. Lancet 1983;1:58.
26. Brooks JJ. Kaposi's sarcoma: a reversible hyperplasia. Lancet 1986;2:1309-11.
27. Azzarelli A, Massaferro V, Quagliuolo V, et al. Kaposi's sarcoma: malignant tumor or proliferative disorder? Eur J Cancer Clin Oncol 1988;24:973-8.
28. Sehested M, Hou-Jensen K. Factor VIII-related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch Pathol Anal 1981;391:217-25.
29. Swanson PE, Wick MR. Immunohistochemical evaluation of vascular neoplasms. Clin Dermatol 1991;9:243-53.
30. Ioachim HL, Adsay V, Giancotti FR, Dorsett B, Melamed J. Kaposi's sarcoma of internal organs: a multiparameter study of 86 cases. Cancer 1995;75:1376-85.
31. Miettinen M, Lindenmayer E, Chaubal A. Endothelial cell markers CD31, CD34 and BNH9 antibody to H and Y antigens: evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol 1994;7:82-90.
32. Cohen PR, Rapini RT, Farhood AI. Expression of the human hematopoietic progenitor cell antigen (CD34) in vascular and spindle cell tumors. J Cutan Pathol 1993;20:15-20.
33. van de Rijn M, Rouse RV. CD34: a review. Appl Immunohistochem 1994;2:71-80.
34. Abenoza P, Lillemoe T. CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Am J Dermatopathol 1993;15:429-34.
35. Hanau CA, Miettinen M. Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995;26:440-9.
36. Renshaw AA, Pinkus GS, Corsen JM. CD34 and AE1/AE3: Diagnostic discriminance in the distinction of solitary fibrous tumor of the pleura from sarcomatoid mesothelioma. Appl Immunohistochem 1994;2:94-102.
37. Flint A, Weiss SW. CD34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma. Hum Pathol 1995;26:428-31.
38. Sirgi KE, Wick MR, Swanson PE. B72.3 and CD34 immunoreactivity in malignant epithelioid soft tissue tumors: adjuncts in the recognition of endothelial neoplasms. Am J Surg Pathol 1993;17: 179-85.
39. Arber DA, Kandalaft PL, Mehta P, Battifora H. Vimentin-negative epithelioid sarcoma: the value of an immunohistochemical panel that includes CD34. Am J Surg Pathol 1993;17:302-7.
40. Albelda SM, Muller WA, Buck CA, Newman PJ. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol 1991;114:1059-61.
41. Stockinger H, Gadd SJ, Eher R, et al. Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol 1990;145:3889-97.
42. McHugh M, Miettinen M. KP1 (CD68): its limited specificity for histiocytic tumors. Appl Immunohistochem 1994;2:186-90.
43. Kurtin PJ, Bonin DM. Immunohistochemical demonstration of the lysosome-associated glycoprotein CD68 (KP1) in granular cell tumors and schwannomas. Hum Pathol 1994;25:1172-8.
44. Kaiserling E, Xiao J-C, Ruck P, Horny H-P. Aberrant expression of macrophage-associated antigens (CD68 and Ki-M1P) by Schwann cells in reactive and neoplastic neural tissue: light and electron microscopic findings. Mod Pathol 1993;6:463-8.
45. Dei Tos AP, Doglioni C, Laurino L, Fletcher CDM. KP1 (CD68) expression in benign neural tumors: further evidence of its low specificity as a histiocytic/myeloid marker. Histopathology 1993; 23:185-7.
46. Smith MEF, Costa MJ, Weiss SW. Evaluation of CD68 and other histiocytic antigens in angiomatoid malignant fibrous histiocytoma. Am J Surg Pathol 1991;15:757-63.