Targeted expression of human vitamin D receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice

Journal of Investigative Dermatology

Volumn 118, Issue 4, 2002, Pages 631-638

  Kong, Juan ^a   Xiao, Jian Li ^a   Gavin, Donna ^a   Jiang, Yulei ^a   Yan, Chun Li ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alopecia; Hair cycle; Hair follicles; Keratin 14 promoter; Keratinocytes; Vitamin D receptor

Indexed keywords

CYTOKERATIN 14; KERATIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDERMIS; ESTHETIC SURGERY; GROWTH RETARDATION; HAIR FOLLICLE; HAIR GROWTH; HYPERPARATHYROIDISM; HYPOCALCEMIA; IMMUNOHISTOCHEMISTRY; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RICKETS; TRANSGENIC MOUSE; WILD TYPE;

EID: 0036226321     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01727.x     Document Type: Article

References (33)

1. The vitamin D story: A collaborative effort of basic science and clinical medicine
2. Cloning of human 25-hydroxyvitamin D-1α-hydroxylase and mutations causing vitamin D-dependent rickets type I
3. The secret life of the hair follicle
4. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
5. FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
6. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable
7. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
8. RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
9. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia
10. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice
11. Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism
12. The vitamin D receptor and the syndrome of hereditary 1, 25-dihydroxyvitamin D-resistant rickets
13. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages
14. Morphogenesis and renewal of hair follicles from adult multipotent stem cells
15. Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction
16. Telogen skin contains an inhibitor of hair growth
17. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle
18. Hair follicle expression of 1, 25-dihydroxyvitamin D3 receptor during the murine hair cycle
19. Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor
20. Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice
21. Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice
22. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
23. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus
24. Hair follicle growth controls
25. Controls of hair follicle cycling
26. Topographical and developmental studies on target sites of 1, 25(OH)2 vitamin D3 in skin
27. rh) mutations, chromosome 14
28. 25-Hydroxyvitamin D3, 1alpha-hydroxylase and vitamin D synthesis
29. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice
30. Transgenic studies with a keratin promoter-driven growth hormone transgene: Prospects for gene therapy
31. Aberrant growth plate development in VDR/RXRgamma double null mutant mice
32. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning