Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin

Endocrinology

Volumn 143, Issue 5, 2002, Pages 1613-1624

  Sidis, Yisrael ^a   Tortoriello, Drew V ^a,c   Holmes, William E ^b   Pan, Yang ^b   Keutmann, Henry T ^a   Schneyer, Alan L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c Presbyterian Hospital ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN A; ACTIVIN RECEPTOR; FOLLISTATIN; FOLLISTATIN RELATED PROTEIN; HEPARIN; MYELOPID; OSTEOGENIC PROTEIN 1; PROTEOHEPARAN SULFATE; RECOMBINANT FOLLISTATIN RELATED PROTEIN; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; CONTROLLED STUDY; DRUG ACTIVITY; ENDOCRINE FUNCTION; EXON; GENE STRUCTURE; HEPARINIZATION; HORMONE BINDING; HORMONE PROTEIN COMPLEX; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYPOTHESIS; INTRON; MALE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RADIOASSAY; RAT; SEQUENCE HOMOLOGY; SOLID; TRANSCRIPTION REGULATION;

EID: 0036224990     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.5.8805     Document Type: Article

References (46)

1. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin
2. Primary structure of the human follistatin precursor and its genomic organization
3. Activin-binding protein from rat ovary is follistatin
4. Characterization of unique binding kinetics of follistatin and activin or inhibin in serum
5. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors
6. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells
7. Activin receptor patterning of foregut organogenesis
8. In vitro control of organogenesis and body patterning by activin during early amphibian development
9. Follistatin and activin: A potential intrinsic regulatory system within diverse tissues
10. Activin-binding protein is present in pituitary
11. Evidence for an autocrine role of activin B within anterior pituitary cultures
12. Characterization and the regulation of inhibin/activin subunit proteins of cultured rat anterior pituitary cells
13. An update on the roles of inhibin, activin, and follistatin as local regulators of folliculogenesis
14. Follistatin antagonizes effects of activin-A on steroidogenesis in human luteinizing granulosa cells
15. Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
16. Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin
17. Follistatin and activin in bone: Expression and localization during endochondral bone development
18. Localization of follistatin, an activin-binding protein, in bone tissues
19. Follistatin, an antagonist of activin, is expressed in the Spemann Organizer and displays direct neuralizing activity
20. Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis
21. Identification of an activin-follistatin growth modulatory system in the human prostate: Secretion and biological activity in primary cultures of prostatic epithelial cells
22. Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development
23. Intravenous administration of follistatin: Delivery to the liver and effect on liver regeneration after partial hepatectomy
24. Advance in the study of inhibin, activin and follistatin production in pregnant women
25. Analysis of human follistatin structure: Identification of two discontinuous N-terminal sequences coding for activin A binding and structural consequences of activin binding to native proteins
26. Follistatin: Essential role for the N-terminal domain in activin binding and neutralization
27. Functions of agrin and agrin-related proteins
28. The biology of SPARC, a protein that modulates cell-matrix interactions
29. Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour
30. Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells
31. Follistatin physiology and potential mechanisms of action in the human
32. Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): Regulation by cell surface follistatin
33. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders
34. Follistatin-related protein (FSRP): A new member of the follistatin gene family
35. Human follistatin-related protein: A structural homologue of follistatin with nuclear localization
36. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family
37. An improved method of purifying inhibin radioligand for radioimmunoassay
38. Electrophoretic purification of radioiodinated follicle-stimulating hormone for radioligand receptor assay and radioimmunoassay
39. Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model
40. Follistatin, an activin binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells
41. Multiple defects and perinatal death in mice deficient in follistatin
42. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
43. Site-specific mutagenesis of human follistatin
44. Activin A in JEG-3 cells: Potential role as an autocrine regulator of steroidogenesis in humans
45. Role of activins in the male reproductive tract
46. Inhibins, activins, and follistatins: The saga continues