The mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species

Chemical Research in Toxicology

Volumn 15, Issue 4, 2002, Pages 506-511

  Bonini, Marcelo G ^a   Mason, Ronald P ^b   Augusto, Ohara ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CARBONIC ACID; HYDROXYL RADICAL; NITRITE; OXYGEN; PEROXYNITRITE; PHENOL DERIVATIVE; TEMPOL;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CHEMOLUMINESCENCE; CONCENTRATION (PARAMETERS); DECOMPOSITION; ELECTRON SPIN RESONANCE; INFLAMMATION; NITRATION; NITROSATION; OXIDATIVE STRESS; PH;

ANTIOXIDANTS; CARBON DIOXIDE; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; NITRATES; NITRO COMPOUNDS; NITROSO COMPOUNDS; OXIDATION-REDUCTION; SPIN LABELS;

ANIMALIA;

EID: 0036223560     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx015571z     Document Type: Article

References (36)

1. Nitroxides as antioxidants
2. The pro-oxidative activity of SOD and nitroxide SOD mimics
3. Beneficial effects oftempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat
4. Effects oftempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury
5. Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy
6. Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis
7. Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
8. Unraveling peroxynitrite formation in biological systems
9. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration
10. Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autoxidation: Direct evidence for a metal independent formation of free radical intermediates
11. Formation of spin trap adducts during the decomposition of peroxynitrite
12. 2 radicals
13. The complex chemistry of peroxynitrite decomposition: New insights
14. 2-catalyzed one-electron oxidations by peroxynitrite: Properties of the reactive intermediate
15. 2: Evidence for a radical formation in a solvent cage
16. Hydroxyl radical formation during peroxynitrous acid decomposition
17. The yield of hydroxyl radical from the decomposition of peroxynitrous acid
18. Radical mechanisms of the decomposition of peroxynitrite and the peroxynitrite-CO(2) adduct and of reactions with L-tyrosine and related compounds as studied by (15)N chemically induced dynamic nuclear polarization
19. Direct EPR detection of carbonate radical anion produced from peroxynitrite and carbon dioxide
20. Cage-escape of geminate radical pairs can produce peroxynitrate from peroxynitrite under a wide variety of experimental conditions
21. Metabolic fate of peroxynitrite in aqueous solution - Reaction with nitric oxide and pH-dependent decomposition to nitrite and oxygen in a 2:1 stoichiometry
22. 2 in a water solution
23. Formation and properties ofperoxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis
24. Nitrosation by peroxynitrite: Use of phenol as a probe
25. Rapid reaction between peroxynitrite ion and carbon dioxide - Implications for biological activity
26. Oxidation of peroxynitrite by inorganic radicals: A pulse radiolysis study
27. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide
28. Stimulation by nitroxides of catalaselike activity of hemeproteins
29. - or as SOD mimics?
30. Carbon dioxide stimulates the production of thiyl, sulfinyl, and dissulfide radical anion from thiol oxidation by peroxynitrite
31. Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite
32. Role of the carbonate radical anion in tyrosine nitration and hydroxylation by peroxynitrite
33. Tyrosine nitration by simultaneous generation of (·)NO and O-(2) under physiological conditions. How the radicals do the job
34. Kinetics of nitroxyl radical reactions. A pulse-radiolysis conductivity study
35. Superoxide reaction with nitroxides