Dimerizer-induced proliferation of genetically modified hepatocytes

Molecular Therapy

Volumn 5, Issue 4, 2002, Pages 420-426

  Li, Zong Yi ^a   Otto, Kevin ^a   Richard, Robert E ^a   Ni, Shaoheng ^a   Kirillova, Irina ^a   Fausto, Nelson ^a   Blau, C Anthony ^a   Lieber, André ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Dimerizer; Gene therapy; Hepatocyte; Proliferation; Retroviral

Indexed keywords

AP 20187; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; GROWTH PROMOTOR; HYBRID PROTEIN; INTERLEUKIN 6 RECEPTOR; RETROVIRUS VECTOR; SCATTER FACTOR RECEPTOR; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; DNA DETERMINATION; DNA MODIFICATION; EMBRYO; FEMALE; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CELL; LIVER REGENERATION; MITOSIS; MOUSE; NONHUMAN; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION; STEM CELL; VIRAL GENE DELIVERY SYSTEM;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0036222251     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0565     Document Type: Article

References (35)

1. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
2. Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver
3. Efficient lentiviral transduction of liver requires cell cycling in vivo
4. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: Cell cycling does not influence hepatocyte transduction
5. A proliferation switch for genetically modified cells
6. Controlling signal transduction with synthetic ligands
7. Targeted expansion of genetically modified bone marrow cells
8. In vivo selection using a cell-growth switch
9. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
10. Liver regeneration
11. Hepatocyte growth factor induces hepatocyte proliferation in vivo and allows for efficient retroviral-mediated gene transfer in mice
12. Effects of keratinocyte and hepatocyte growth factor in vivo: Implications for retrovirus-mediated gene transfer to liver
13. Thrombopoietin and its receptor
14. Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells
15. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: Identification of a human hepatic progenitor cell?
16. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
17. Bone marrow as a potential source of hepatic oval cells
18. Versatile retoviral vectors for potential use in gene therapy
19. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha
20. Retroviral gene transfer into primary hepatocytes: Implications for genetic therapy of liver-specific functions
21. A modified urokinase plasminogen activator induces liver regeneration without bleeding
22. Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo
23. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
24. Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells
25. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
26. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype
27. Interleukin-6 family of cytokines and gp130
28. Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes
29. Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells
30. Adenovirus-mediated transfer of the amphotropic retrovirus receptor cDNA increases retroviral transduction in cultured cells
31. Method for multiple portal vein infusions in mice: Quantification of adenovirus mediated hepatic gene transfer
32. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
33. A Fas-based suicide switch in human T cells for the treatment of graft- versus-host disease
34. The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion
35. Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization