Sensitizing effects of lafutidine on CGRP-containing afferent nerves in the rat stomach

British Journal of Pharmacology

Volumn 135, Issue 6, 2002, Pages 1487-1494

  Nishihara, Katsushi ^a   Nozawa, Yoshihisa ^a   Nakano, Motoko ^a   Ajioka, Hirofusa ^a   Matsuura, Naosuke ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Afferent nerve; CGRP; Lafutidine; Nitric oxide; Sensitization; VR1

Indexed keywords

ANTIULCER AGENT; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; HISTAMINE H2 RECEPTOR ANTAGONIST; LAFUTIDINE; NITRIC OXIDE; RESINIFERATOXIN; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MALE; MICRODIALYSIS; MODULATION; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SENSITIZATION; SENSORY NERVE; STOMACH INNERVATION; STOMACH PROTECTION; TRANSPORT KINETICS;

EID: 0036221114     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704596     Document Type: Article

References (52)

1. Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents
2. 2-receptor antagonist, on the recurrence of gastric ulcer after healing by drug treatment in rats
3. Nitric oxide donors increase mucus gel thickness in rat stomach
4. Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells
5. Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa
6. The neuropharmacology of capsaicin: Review of some recent observations
7. Nitric oxide synthase and arginase in cells isolated from the rat gastric mucosa
8. The capsaicin receptor: A heat-activated ion channel in the pain pathway
9. Interaction of endogenous nitric oxide and CGRP in sensory neuron- induced gastric vasodilation
10. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
11. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture
12. Pharmacological evidence for the involvement of multiple calcitonin gene-related peptide (CGRP) receptors in the anti-secretory and antiulcer effect of CGRP in rat stomach
13. A sensitive sandwich enzyme immunoassay for calcitonin gene-related peptide (CGRP): Characterization and application
14. Expression of constitutive nitric oxide synthase in rat and human gastrointestinal tract
15. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig
16. Neural emergency system in the stomach
17. Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach
18. Sensory neurons mediate protective vasodilatation in rat gastric mucosa
19. Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach
20. Effects of 3-hydroxymethylimidazo [2,1-b] benzothiazole (NIK-228) on gastric acid secretion and various experimental peptic ulcers in rats
21. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
22. Effects of acid-inhibitory antiulcer drugs on mucin biosynthesis in the rat stomach
23. Lafutidine-induced stimulation of mucin biosynthesis mediated by nitric oxide is limited to the surface mucous cells of rat gastric oxyntic mucosa
24. Capsaicin-induced calcitonin gene-related peptide release from isolated rat stomach measured with a new chemiluminescent enzyme immunoassay
25. Neural and non-neural origin of calcitonin gene-related peptide (CGRP) in the gastric mucosa
26. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers
27. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat
28. Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin
29. Characterization of gastric mucosal blood flow response induced by intragastric capsaicin in rats
30. Distribution and characterization of vanilloid receptors in the rat stomach
31. 2-receptor antagonistic activity
32. 2-receptor antagonist, in rats
33. Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats
34. Effect of lafutidine, a novel antiulcer agent, on healing and relapse of acetic acid-induced gastric ulcer in rats
35. Constitutive nitric oxide synthases in rat gastric mucosa: Subcellular distribution, relative activity and different carboxyl-terminal antigenicity of the neuronal form compared with cerebellum
36. Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat
37. Nitric oxide synthase-containing neurons in sensory ganglia of the rat are susceptible to capsaicin-induced cytotoxicity
38. A graphic method for the determination and presentation of binding parameters in a complex system
39. 2 receptor antagonist, in rats and dogs
40. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats
41. Vanilloid (capsaicin) receptors and mechanisms
42. Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum
43. Immunohistochemical localization of calcitonin gene-related peptide in the human gastric mucosa
44. The cloned capsaicin receptor integrates multiple pain-producing stimuli
45. Influence of capsaicin-sensitive afferent fibers on acetic acid-induced chronic gastric ulcers in rats
46. The receptor occupation and plasma concentration of NKY-722, a water-soluble dihydropyridine-type calcium antagonist, in spontaneously hypertensive rats
47. Increased expression of neuronal nitric oxide synthase in dorsal root ganglion neurons after systemic capsaicin administration
48. Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: Integrity in the balance
49. Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin
50. Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of couscious rats
51. A sustained occupancy in vivo of cadiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats
52. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide