Production and in vivo testing of a recombinant bovine IL-12 as an adjuvant for Salmonella Typhimurium vaccination in calves

Veterinary Immunology and Immunopathology

Volumn 86, Issue 1-2, 2002, Pages 23-30

  Takehara, Kazuaki ^a   Kikuma, Reiko ^a   Ishikawa, Satoko ^a   Kamikawa, Makiyo ^a   Nagata, Tomoshi ^a   Yokomizo, Yuichi ^b   Nakamura, Masayuki ^a  

^a KITASATO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Adjuvant; Baculovirus; Bovine IL 12; Cytokines; Th1 response

Indexed keywords

DIMER; HISTIDINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; MONOMER; NICKEL COMPLEX; PROTEIN P35; PROTEIN P40; RECOMBINANT INTERLEUKIN 12; SALMONELLOSIS VACCINE; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATTLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PURIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VIVO STUDY; MALE; MONONUCLEAR CELL; NONHUMAN; SALMONELLA TYPHIMURIUM; TH1 CELL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; CATTLE; CATTLE DISEASES; DIMERIZATION; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-12; MALE; RECOMBINANT PROTEINS; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SALMONELLA VACCINES; TH1 CELLS; VACCINES, INACTIVATED;

BOVINAE; INSECTA; SALMONELLA; SALMONELLA TYPHIMURIUM; UNIDENTIFIED BACULOVIRUS;

EID: 0036217835     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(02)00009-0     Document Type: Article

References (27)

1. IL-12 is a potent neonatal vaccine adjuvant
2. IL-12 is an effective adjuvant for induction of mucosal immunity
3. CD4+ T-lymphocyte and immunoglobulin G2 responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge
4. Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme
5. Production of interleukin-12 as a self-processing 2A polypeptide
6. Bovine interleukin-12 and modulation of IFN-γ production
7. IFN-γ stimulates IgG2 production from bovine B cells co-stimulated with anti-μ and mitogen
8. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
9. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
10. IL-12 and IFN-γ in host defense against mycobacteria and Salmonella in mice and men
11. Linearization of baculovirus DNA enhances the recovery of recombinant virus expression vector
12. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
13. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
14. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
15. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses
16. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin
17. Baculovirus expression vectors: The requirements for high level expression of proteins, including glycoproteins
18. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
19. Heterogeneity of cytokine secretion patterns and functions of helper T cells
20. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
21. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
22. Expression of a bioactive bovine interleukin-12 using baculovirus
23. Interleukin-12 as an adjuvant promotes immunoglobulin G and type 1 cytokine recall responses to major surface protein 2 of the ehrlichial pathogen Anaplasma marginale
24. Cattle immune responses to tetanus toxoid elicited by recombinant S. typhimurium vaccines or tetanus toxoid in alum or Freund's adjuvant
25. Development and in vitro characterization of recombinant vaccinia viruses expressing bovine leukemia virus gp51 in combination with bovine IL4 or IL12
26. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
27. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12