Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 114-121

  Marinaro, Mariarosaria ^a   Boyaka, Prosper N ^a   Jackson, Raymond J ^a   Finkelman, Fred D ^b   Kiyono, Hiroshi ^c   Jirillo, Emilio ^d   McGhee, Jerry R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA VACCINE; INTERLEUKIN 12; TETANUS TOXOID;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CHOLERA; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; IMMUNOGENICITY; IMMUNOREGULATION; INTERFERON PRODUCTION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TARGET CELL;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, CD4; CELLS, CULTURED; CHOLERA TOXIN; CYTOKINES; EPITOPES, T-LYMPHOCYTE; INTERFERON TYPE II; INTERLEUKIN-12; LIPOSOMES; MICE; MICE, INBRED C57BL; NASAL MUCOSA; SPLEEN; TETANUS TOXOID; TH1 CELLS; TH2 CELLS; VACCINES, COMBINED;

EID: 0032960196     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
2. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, M. P. Beckman, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
3. + T cells. Annu. Rev. Immunol. 12:635.
4. Marinaro, M., H. F. Staats, T. Hiroi, R. J. Jackson, M. Coste, P. N. Boyaka, N. Okahashi, M. Yamamoto, H. Kiyono, H. Bluethmann, K. Fujihashi, and J. R. McGhee. 1995. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155:4621.
5. Marinaro, M., P. N. Boyaka, F. D. Finkelman, H. Kiyono, R. J. Jackson, E. Jirillo, and J. R. McGhee. 1997. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type response to an oral vaccine without altering mucosal IgA responses. J. Exp. Med. 185:415.
6. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
7. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
8. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa-associated tissues. J. Exp. Med. 178:1309.
9. Vajdy, M., M. H. Kosco-Vilbois, M. Kopf, G. Kohler, and N. Lycke. 1995. Impaired mucosal immune responses in interleukin 4-targeted mice. J. Exp. Med. 181:41.
10. + T cells. J. Immunol. 154:5071.
11. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste-Amezaga, S. H. Chan, M. Kobayashi, D. Young, E. Nickberg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
12. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
13. + T cells to enhance priming for interferon γ production and diminished interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
14. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
15. Robertson, M. J., R. J. Soiffer, S. F. Wolf, T. J. Manley, C. Donahue, D. Young, S. H. Herrmann, and J. Ritz. 1992. Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med. 175:779.
16. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. S. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721.
17. Sypek, J. P., C. L. Chung, S. E. H. Nayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type I immune response. J. Exp. Med. 177:1797.
18. Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by Schistosome infection. Nature 376:594.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
20. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
21. Finkelman, F. D., K. B. Madden, A. W. Cheever, I. M. Katona, S. C. Morris, M. K. Gately, B. R. Hubbard, W. C. Gause, and J. F. Urban. 1994. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563.
22. Germann, T., S. Guckes, M. Bongartz, H. Dlugonska, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE. Int. Immunol. 7:1649.
23. Staats, H. F., W. G. Nichols, and T. J. Palker. 1996. Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide TISP10 MN(A). J. Immunol. 157:462.
24. Yamamoto, S., H. Kiyono, M. Yamamoto, K. Imaoka, M. Yamamoto, K. Fujihashi, F. W. van Ginkel, M. Noda, Y. Takeda, and J. R. McGhee. 1997. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc. Natl. Acad. Sci. USA 94:5267.
25. Jackson, R. J., K. Fujihashi, J. Xu-Amano, H. Kiyono, C. O. Elson, and J. R. McGhee. 1993. Induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun. 61:4272.
26. Baqar, S., N. D. Pacheco, and F. M. Rollwagen,. 1993. Modulation of mucosal immunity against Campylobacter jejuni by orally administered cytokines. Antimicrob. Agents Chemother. 37:2688.
27. Rollwagen, F. M., and S. Baqar. 1996. Oral cytokine administration. Immunol. Today 17:548.
28. Woogen, S. D., W. Ealding, and C. O. Elson 1987. Inhibition of murine lymphocyte proliferation by the B subunit of cholera toxin. J. Immunol. 139:3764.
29. Lycke, N., A. K. Bromander, L. Ekman, U. Karlsson, and J. Holmgren. 1989. Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo. J. Immunol. 142:20.
30. Miller, J. F., J. J. Mekalanos, and S. Falkow. 1989. Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243:916.
31. Hill, S. J., and J. L. Ebersole. 1991. Cholera toxin synergizes LPS- and IL-1 beta-induced PGE2 release: potential amplification systems in cholera. Lymphokine Cytokine Res. 10:449.
32. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108.
33. Naito, Y., H. Endo, K. Arai, R. L. Coffman, and N. Arai. 1996. Signal transduction in Th clones: target of differential modulation by PGE2 may reside down-stream of the PKC-dependent pathway. Cytokine 8:346.
34. Westermann, J., and R. Pabst. 1992. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin. Invest. 70:539.
35. Scott, H., T. Halstensen, and P. Brandtzaeg. 1993. The immune system of the gastrointestinal tract. Pediatr. Allergy Immunol. 4:7.
36. Pabst, R., and T. Tschernig. 1995. Lymphocytes in the lung: an often neglected cell: numbers, characterization and compartmentalization. Anat. Embryol. 192: 293.
37. + T cells. Eur. J. Immunol. 24:343.
38. Romani, L., A. Mencacci, L. Lonnetti, R. Spaccapelo, E. Cenci, P. Puccetti, S. F. Wolf, and F. Bistoni. 1994. IL-12 is both required and prognostic in vivo for T helper type I differentiation in murine candidiasis. J. Immunol. 153: 5167.
39. Li, L., D. Young, S. F. Wolf, and Y. S. Choi. 1996. Interleukin-12 stimulates B cell growth by inducing IFN-gamma. Cell. Immunol. 168:133.
40. Metzger, D. W., R. M. McNutt, J. T. Collins, J. M. Buchanan, C. V. Van, and W. A. Dunnick. 1997. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-gamma-dependent and -independent mechanisms. Eur. J. Immunol. 27:1958.