Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells

Cancer Letters

Volumn 126, Issue 2, 1998, Pages 227-233

  Lecureur, Valérie ^a   Guillouzo, André ^a   Fardel, Olivier ^a,b  

^a INSERM   (France)

^b Lab de Physiol et d'Hematologie   (France)

Author keywords

Drug transport; Hepatocarcinogenesis; Hepatocytes; Organic cation transporter; Tetraethylammonium

Indexed keywords

CARRIER PROTEIN; DIETHYLNITROSAMINE; MESSENGER RNA; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG TRANSPORT; GENE EXPRESSION; HEPATOMA CELL; LIVER CELL CARCINOMA; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; DIETHYLNITROSAMINE; FEMALE; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; NEOPLASM PROTEINS; ORGANIC CATION TRANSPORTER 1; RATS; RNA, MESSENGER; TETRAETHYLAMMONIUM;

ANIMALIA; APOGON BRACHYGRAMMUS;

EID: 0031953589     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00018-4     Document Type: Article

References (30)

1. Oude Elferink R.P.J., Meijer D.K.F., Kuipers F., Jansen P.L.M., Groen A.K., Groothuis G.M.M. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim. Biophys. Acta. 1241:1995;215-268.
2. Hayes J.D., Wolf R. Molecular mechanism of drug resistance. Biochem. J. 272:1990;281-295.
3. Grundemann D., Gorboulev V., Gambaryan S., Veyhl M., Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 372:1994;549-552.
4. Martel F., Vetter T., Russ H., Grundemann D., Azevedo I., Koepsell H., Schomig E. Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch. Pharmacol. 354:1996;320-326.
5. Busch A.E., Quester S., Ulzheimer J.C., Waldegger S., Gorboulev V., Arndt P., Lang F., Koepsell H. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J. Biol. Chem. 271:1996;32599-32604.
6. Busch A.E., Quester S., Ulzheimer J.C., Gorboulev V., Akhoundova A., Waldegger S., Lang F., Koepsell H. Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 395:1996;153-156.
7. Teeter L.D., Becker F.F., Chisari F.V., Li D., Kuo M.T. Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol. Cell. Biol. 10:1990;5728-5735.
8. Fardel O., Loyer P., Lecureur V., Glaise D., Guillouzo A. Constitutive expression of functional P-glycoprotein in rat hepatoma cells. Eur. J. Biochem. 219:1993;521-528.
9. Fairchilds C.R., Ivy S.P., Rushmore T., Lee G., Koo P., Goldsmith M.E., Myers C.E., Farber E., Cowan K.H. Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc. Natl. Acad. Sci. USA. 84:1987;7701-7705.
10. Thorgeirsson S.S., Huber B.E., Sonel S., Fojo A., Pastan I., Gottesman M.M. Expression of the multidrug resistance gene in hepatocarcinogenesis and regenerating liver. Science. 236:1987;1120-1122.
11. Scherer E., Emmelot P. Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat. Eur. J. Cancer. 11:1975;145-154.
12. Beaumont C., Lerumeur E., Guillouzo C., Latinier M.F., Bourel M., Guillouzo A. Ferritin is increased in diethylnitrosamine altered rat hepatocytes. Biochem. Biophys. Res. Commun. 99:1981;879-885.
13. Deschatrette J., Weiss M.C. Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie. 56:1974;1603-1611.
14. Thompson E.B., Tomkins G.M., Curran J.F. Induction of tyrosine ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line. Biochemistry. 56:1966;296-303.
15. Guguen C., Guillouzo A., Boisnard M., Le Cam A., Bourel M. Etude ultrastructurale de monocouches d'hepatocytes de rat cultivés en présence d'hémisuccinate d'hydrocortisone. Biol. Gastroenterol. 8:1975;223-231.
16. Fardel O., Lecureur V., Guillouzo A. Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes. FEBS Lett. 327:1993;189-193.
17. Chirgwin J.M., Przybyla E.A., MacDonald R.J., Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
18. Raymondjean M., Kneip B., Schapira G. Preparation and characterization of mRNAs from rat heart muscle. Biochimie. 65:1983;65-70.
19. Pemble S., Taylor J.B., Ketterer B. Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker. Biochem. J. 240:1986;885-889.
20. Sargent T.D., Wu J.R., Sala-Trepat J.M., Wallace R.B., Reyes A.A., Bonner J. The rat serum albumin gene: analysis of cloned sequences. Proc. Natl. Acad. Sci. USA. 76:1979;3256-3260.
21. Levavasseur F., Mayer U., Guillouzo A., Clement B. Influence of nidogen complexed or not with laminin on attachment, spreading, albumin and laminin B2 mRNA levels of rat hepatocytes. J. Cell Physiol. 161:1994;257-266.
22. Bradford M.M. Rapid sensitive method for the quantification of microgram quantities of proteins utilizing the principal of protein dye binding. Anal. Biochem. 72:1976;248-254.
23. Satoh K., Kitahara A., Soma Y., Inaba Y., Hatayama I., Sata K. Purification, induction and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc. Natl. Acad. Sci. USA. 82:1985;3964-3968.
24. Farber E. Cellular biochemistry of the stepwise development of cancer with chemicals: GHA Clowes memorial lecture. Cancer Res. 44:1984;5463-5474.
25. Schwarz L.R., Watkins J.B. Uptake of taurocholate, a vecuronium-like organic cation, ORG 9426, and ouabain into carcinogen-induced diploid and polyploid hepatocytes obtained by centrifugal elutriation. Biochem. Pharmacol. 43:1992;1195-1201.
26. A. Guillouzo, C. Chesne, Xenobiotic metabolism in epithelial cell cultures, in: A.J. Shaw (Ed.), Cell Culture Models of Epithelial Tissues: A Practical Approach, Oxford University Press, Oxford, 1996, pp. 67-85.
27. Boyer J.L., Hagenbush B., Ananthanarayanan M., Suchy F., Stieger B., Meier P.J. Phylogenic and ontogenic expression of the hepatocellular bile acid transport. Proc. Natl. Acad. Sci. USA. 90:1993;435-438.
28. Clayton D.F., Darnell J.E. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol. Cell. Biol. 3:1983;1552-1561.
29. De Waziers I., Bouguet J., Beaune P.H., Gonzalez F.J., Ketterer B., Barouki R. Effects of ethanol, dexamethasone and RU486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase in a rat hepatoma cell line (Fao). Pharmacogenetics. 2:1992;12-18.
30. Padgham C.R.W., Paine A.J. Altered expression of cytochrome P-450 mRNAs and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes. Biochem. J. 289:1993;621-624.