Including measured genotypes in statistical models to study the interplay of multiple factors affecting complex traits

Behavior Genetics

Volumn 32, Issue 1, 2002, Pages 1-22

  Van den Oord, Edwin J C G ^a   Snieder, Harold ^b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Association study; Complex traits; Mx; Population stratification; Structural equation modeling

Indexed keywords

ALLELISM; ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; COMPUTER SIMULATION; CONCEPT FORMATION; DATA ANALYSIS; GENE LOCUS; GENETIC MARKER; GENETIC TRAIT; GENOTYPE; HAPLOTYPE; HEREDITY; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; MULTIFACTORIAL GENETIC DISORDER; RESTRICTION MAPPING; STATISTICAL MODEL; STRUCTURE ANALYSIS; TREATMENT OUTCOME; VARIABLE NUMBER OF TANDEM REPEAT;

GENE FREQUENCY; GENOTYPE; HUMANS; MATHEMATICAL COMPUTING; MODELS, GENETIC; MODELS, STATISTICAL; MULTIFACTORIAL INHERITANCE; PEDIGREE; SOFTWARE; VARIATION (GENETICS);

EID: 0036209084     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014474711118     Document Type: Article

References (64)

1. A general test of association for quantitative traits in nuclear families
2. Factor analysis and AIC
3. Transmission-disequilibrium tests for quantitative traits
4. Sibling-based tests of linkage and association for quantitative traits
5. Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure
6. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods
7. Analysis of transformations
8. Asymptotically distribution free methods for the analysis of covariance structures
9. A note on the application of the transmission disequilibrium test when a parent is missing
10. Genomic control for association studies
11. Informative drop-out in longitudinal data analysis
12. Fitting multivariate normal finite mixtures subject to structural equation modeling
13. Power and sample size calculations for case-control studies of gene-environment interactions with a polytomous exposure variable
14. Combined linkage and association sib-pair analysis for quantitative traits
15. Additive-multiplicative approximation of genotype-environment interaction
16. Power comparison of various sibship tests of association
17. Fitting Johnson curves by moments
18. Systems of frequency curves generated by methods of translation
19. A general method for estimating a linear structural equation system
20. The problem of error rate inflation in covariance structure models
21. A twin study of recent life events and difficulties
22. Genetic and epidemiologic approaches to the search for gene-environment interaction: The case of osteoporosis
23. An epidemiologic approach to ecogenetics
24. Nontraditional epidemiologic approaches in the analysis of gene-environment interaction: Case-control studies with no controls
25. Extensions to pedigree analysis: III. Variance components by the scoring method
26. Gene-environment interaction and twin studies
27. Genetic influence on risk of divorce
28. A comparison of some methodologies for the factor analysis of non-normal Likert variables
29. Quantitative genetic analysis of injury liability in infants and toddlers
30. Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies
31. Child development, molecular genetics, and what to do with genes once they are found
32. Use of unlinked genetic markers to detect population stratification in association studies
33. Transmission-disequilibrium test for quantitative trait loci
34. Choosing near-linear parameters in the four-parameter logistic model for radioligand and related assays
35. Genetics of HLA disease associations: The use of the haplotype relative risk (HRR) and the "haplo-delta" (DH) estimates in juvenile diabetes from three racial groups
36. Relative-risk regression models using cases and their parents
37. Case-parents design for gene-environment interaction
38. Genotype relative-risks and association tests for nuclear families with missing parental data
39. The future of genetic epidemiology
40. Estimating the dimension of a model
41. Biological complexity and strategies for finding DNA variations responsible for inter-individual variation in risk of common chronic disease, coronary artery disease
42. Age-dependency of gene expression in plasma lipid, lipoprotein and apolipoprotein levels
43. Dissecting the genetic architecture of lipids, lipoproteins and apolipoproteins. Lessons from twin studies
44. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
45. Mapping disease genes: Family-based association studies
46. Models of treatment seeking for alcoholism: The role of genes and environment
47. A comparison between different designs and tests to detect QTLs in association studies
48. Method to detect genotype-environment interactions for quantitative trait loci in association studies
49. The use of mixture models to perform quantitative tests for linkage disequilibrium, maternal effects, and parent-of-origin effects with incomplete subject-parent triads
50. A note on the use of the tobit approach for test scores with floor or ceiling effects
51. Allowing for missing parents in genetic studies of case-parent triads
52. Implications of pharmacogenetic polymorphisms for human health
53. TDT statistics for mapping quantitative trait loci