Functional study of multidrug resistance with fluorescent dyes. Limits of the assay for low levels of resistance and application in clinical samples

Cancer Letters

Volumn 106, Issue 1, 1996, Pages 59-68

  Canitrot, Yvan ^a   Lahmy, Sylvie ^b   Buquen, Jean Jacques ^c   Canitrot, Damien ^d   Lautier, Dominique ^e  

^a Laboratoire de Pharmacologie Medicale et Clinique   (France)

^b UNIVERSITÉ DE PERPIGNAN   (France)

^c CH de Perpignan   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

Hoechst 33342; Leukemia; Multidrug resistance; Rhodamine 123

Indexed keywords

DAUNORUBICIN; FLUORESCENT DYE; HOE 33342; RHODAMINE 123; VINBLASTINE;

ANIMAL CELL; ARTICLE; ASSAY; CELL POPULATION; LEUKEMIA CELL LINE; LYMPHOCYTE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALIA;

EID: 0030598938     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04301-7     Document Type: Article

References (33)

1. [1] Riordan, J.R., Deuchars, K., Kartner, N., Alon, N., Trent, J. and Ling, V. (1985) Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature, 316, 817-819.
2. [2] Beck, W.T. (1987) The cell biology of multiple drug resistance. Biochem. Pharmacol., 36, 2879-2887.
3. [3] Gottesman, M.M. and Pastan, I. (1988) The multidrug transporter, a double-edged sword. J. Biol. Chem., 263, 12163-12166.
4. [4] Neyfakh, A.A. (1988) Use of fluorescent dyes as molecular probes for the study of multidrug resistance. Exp. Cell Res., 174, 168-176.
5. [5] Kessel, D., Beck, W.T., Kukuruga, D. and Schulz, V. (1991) Characterization of multidrug resistance by fluorescent dyes. Cancer Res., 51, 4665-4670.
6. [6] Bucana, C., Giavazzi, R., Nayar, R., O'Brian, C., Seid, C., Earnest, L.E. and Fan, D, (1990) Retention of vital dyes correlates inversely with the multidrug-resistant phenotype of adriamycin-selected murine fibrosarcoma variants. Exp. Cell Res., 190, 69-75.
7. [7] Weaver, J.L., Scott-Pine, P., Aszalos, A., Schoelein, P.V., Currier, S.J., Padmanabhan, R. and Gottesman, M.M. (1991) Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells. Exp. Cell Res., 196, 323-329.
8. [8] Salmon, J.M., Canitrot, Y., Lautier, D., Lahmy, S., Vigo, J. and Viallet, P. (1992) Multiwavelength videomicrofluorometry and multiparametric analysis: application to the detection of multidrug-resistance in single living cells. J. Cell. Pharmacol., 3, 86-94.
9. [9] Lampidis, T.J., Munck, J.N., Krishan, A. and Tapiero, H. (1985) Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells. Cancer Res., 45, 2626-2631.
10. [10] Kessel, D. (1989) Exploring multidrug resistance using rhodamine 123. Cancer Commun., 1, 145-149.
11. [11] Wall, D.M., Sparrow, R., Hu, X.F., Nadalin, G., Zalcberg, J.R., Marschner, I.C., Van der Weyden, M. and Parkin, J.D. (1993) Clinical application of a rapid, functional assay for multidrug resistance based on the accumulation of the fluorescent dye, fluo-3. Eur. J. Cancer, 29A, 1024-1027.
12. [12] Lautier, D., Lahmy, S., Canitrot, Y., Vigo, J., Viallet, P. and Salmon, J.M. (1993) Detection of human leukemia cells with multidrug-resistance phenotype using multilabeling with fluorescent dyes. Anticancer Res., 13, 1557-1564.
13. [13] Vigo, J., Salmon, J.M., Lahmy, S. and Viallet, P. (1991) Fluorescent image cytometry: from qualitative to quantitative measurements. Anal. Cell Pathol., 3, 145-165.
14. [14] Canitrot, Y., Lautier, D., Lahmy, S., Vigo, J., Viallet, P. and Salmon, J.M. (1993) Nile red labeling of single living cells for contour delineation to quantify and evaluate the distributton of rhodamine 123 with fluorescence image cytometry. J. Histochem, Cytochem., 41, 1785-1793.
15. [15] Deffie, A.M., Alam, T., Seneviratne, C., Beeken, S.W., Batra, J.K., Shea, T.C., Henner, W.D, and Goldenberg, G.J. (1988). Multifactorial resistance to Adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of Adriamycin-sensitive and -resistant P388 leukemia. Cancer Res., 48, 3595-3602.
16. [16] Teicher, B.A., Cucchi, C.A., Lee, J.B., Flatow, J.L., Rosowsky, A. and Frei, III, E. (1986). Alkylating agents: in vitro studies of cross-resistance patterns in human cell lines. Cancer Res., 46, 4379-4383.
17. [17] Bellamy, W.T., Dalton, W.S., Gleason, MC., Grogan, T.M. and Trent, J.M. (1991) Development and characterization of a melphalan-resistant human multiple myeloma cell line. Cancer Res., 51, 995-1002.
18. [18] Singer, C.R.J. and Linch, D.C. (1987) Comparison of the sensitivity of normal and leukaemic myeloid progenitors to in-vitro incubation with cytotoxic drugs: a study of pharmacological purging. Leukemia Res., 11, 953-959.
19. [19] Zamora, J.M., Pearce, H.L. and Beck, W.T, (1988) Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol. Pharmacol., 33, 454-462.
20. [20] Ludescher, C., Thaler, J., Drach, D., Drach, J., Spitaler, M., Gattringer, C., Huber, H. and Hofman, J. (1992) Detection of activity of P-glycoprotein in human tumor samples using rhodamine 123. Br. J. Haematol., 82, 161-168.
21. [21] Lahmy, S., Lautier, D., Canitrot, Y., Laurent, G. and Salmon, J.M. (1993) Staining with Hoechst 33342 and rhodamine 123: an attempt to detect multidrug resistant phenotype cells in leukemia. Leukemia Res., 17, 1021-1029.
22. [22] Chabner, B.A., Bates, S.E., Fojo, A.T., Spolyar, M. and Wilson, W.H. (1994) Drug resistance in adult lymphomas. Semin. Hematol., 31, 70-87.
23. [23] Marie, J.P., Zittoun, R. and Sikic, B.I. (1991) Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity. Blood, 78, 586-592.
24. [24] Almquist, K.C., Loe, D.W., Hipfner, D.R., Mackie, J.E., Cole, S.P.C. and Deeley, R.G. (1995) Characterization of the Mr 190,000 multidrug resistance protein in drug-selected and transfected human tumor cells. Cancer Res., 55, 102-110.
25. [25] Versantvoort, C., Broxterman, H., Pinedo, H., de Vries, E.G.E., Feller, N., Kuiper, C. and Lankelma, J. (1992) Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression. Cancer Res., 52, 17-23.
26. [26] Grant, C.E., Valdimarsson, G., Hipfner, D.R., Almquist, K.C., Cole, S.P.C. and Deeley, R.G. (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res., 54, 357-361.
27. [27] Burger, H., Nooter, K., Sonneveld, P., van Wingerden, K.E., Zaman, G.J. and Stoter, G. (1994) High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukemia. Br. J. Haematol., 88, 348-356.
28. [28] Hart, S.M., Ganeshagurn, K., Hoffbrand, A.V., Prentice, H.G. and Mehta, A.B. (1994) Expression of the multidrug resistance-associated protein (MRP) in acute leukemia. Leukemia, 8, 2163-2168.
29. [29] Zhou, D.C., Zittoun, R. and Marie, J.P. (1995) Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia. Leukemia, 9, 1661-1666.
30. [30] Schuurhuis, G.J., Broxterman, H.J., Ossenkoppele, G.J., Baak, J.P.A., Eekman, C.A., Kuiper, C.M., Feller, N., van Heijningen, T.H.M., Klumper, E., Pieters, R., Lankelma, J. and Pinedo, H.M. (1995) Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-b-D-arabinofuranosyl-cytosine sensitivity may predict clinical response in acute myeloid leukemia. Clin. Cancer Res., 1, 81-93.
31. [31] Schneider, E., Cowan, K.H., Bader, H., Toomey, S., Schwartz, G.N., Karp, J.E., Burke, P,J. and Kaufman, S.H. (1995) Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia. Blood, 85, 186-193.
32. [32]. Burger, H., Nooter, K., Zaman, G.J.R., Soneveld, P., van Wingerden, K.E., Oostrum, R.G. and Stoter, G. (1994) Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia, 8, 990-997.
33. [33] Cole, S.P.C., Sparks, K.E., Fraser, K., Loe, D.W., Grant, C.E., Wilson, G.M. and Deeley, R.G. (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54, 5902-5910.