Inhibition of liver fibrosis in LEC rats by a carotenoid, lycopene, or a herbal medicine, Sho-saiko-to

Hepatology Research

Volumn 22, Issue 3, 2002, Pages 196-205

  Kitade, Yukihiro ^a   Watanabe, Seishiro ^a   Masaki, Tsutomu ^a   Nishioka, Mikio ^a   Nishino, Hoyoku ^b  

^a KAGAWA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Fibrosis; LEC rats; Lycopene; Sho saiko to

Indexed keywords

ALPHA ACTIN; CAROTENOID; HERBACEOUS AGENT; IRON; LIPID PEROXIDE; LYC O MATO; LYCOPENE; MALONALDEHYDE; XIAO CHAI HU TANG;

AGE; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; FIBROGENESIS; HISTOPATHOLOGY; LIVER FIBROSIS; LIVER LEVEL; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SMOOTH MUSCLE; STELLATE CELL;

EID: 0036207057     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(01)00132-2     Document Type: Article

References (47)

1. Fibrosis and carcinogenesis
2. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene
3. Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat
4. Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride
5. Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats
6. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans cinnamon rats
7. Animal model the LEC rat: A model for human hepatitis, liver cancer, and much more
8. High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis
9. Spontaneous hepatitis in an inbred strain of Long-Evans rats
10. Chronic liver injury promotes hepatocarcinogenesis of the LEC rat
11. Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9)
12. Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells
13. Effects of the Japanese herbal medicine Sho-saiko-to (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C
14. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CC14-induced liver injury in the rat
15. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
16. Antioxidants in the prevention of renal disease
17. Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4-hydroxybutyl)nitrosamine initiation
18. Consumption of vegetables reduces genetic damage in humans: First results of a human intervention trial with carotenoid-rich foods
19. Modified elastic tissue-Masson trichrome stain
20. A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation
21. Clinical significance of serum hyaluronan in patients with chronic viral liver disease
22. Determination of malondialdehyde precursor in tissue by thiobarbituric acid test
23. Postcolumn fluorometric detection system for liquid chromatographic analysis of amino and imino acids using o-phthaldehyde/N-acetyl-L-cysteine reagent
24. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease
25. Iron removal for prophylaxis of Long-Evans cinnamon (LEC) rat fulminant hepatitis
26. Ironic insult added to copper injury
27. Changes in free radical-metabolizing enzymes and lipid peroxides in the liver of Long-Evans with cinnamon-like coat color rats
28. Oxidative stress in LEC rats evaluated by plasma antioxidants and free fatty acids
29. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats
30. Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expression in cultured rat hepatic stellate cells
31. Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats
32. Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study
33. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer
34. Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer
35. Antioxidants and cancer: Molecular mechanism
36. Tocopherols and the etiology of colon cancer
37. Molecular regulation of hepatic fibrogenesis
38. Cytokine regulation of hepatic stellate cells in liver fibrosis
39. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture
40. Effects of Sho-saiko-to extract on fibrosis and regeneration of the liver in rats
41. Oxygen tension controls collagen type I transcription
42. Modulation of fibroblast proliferation by oxygen free radicals
43. Activation of hepatic stellate cells by TGF α and collagen type IIs mediated by oxidative stress through c-myb expression
44. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents
45. Quantitative analysis of liver fibrosis and stellate cell changes in patients with chronic hepatitis C after interferon therapy
46. Fibrosis accelerates the development of enzyme-altered lesions in the rat liver
47. Prevention of fibrosis reduces enzyme-altered lesions in the rat liver