DNA therapy for asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 2, Issue 1, 2002, Pages 69-73

  Kline, Joel N ^a  

^a UNIVERSITY OF IOWA HEALTH CARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CHEMOTACTIC FACTOR; DNA; INTERLEUKIN 18; STEM CELL FACTOR; TRANSCRIPTION FACTOR GATA 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ASTHMA; ATOPY; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CPG ISLAND; DRUG EFFICACY; GENE THERAPY; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRAL GENE DELIVERY SYSTEM;

EID: 0036205157     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200202000-00011     Document Type: Review

References (13)

1. Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
2. Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma
3. II-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity
4. Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperreactivity in a murine asthma model
5. CpG motifs in bacterial DNA trigger direct B-cell activation
6. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
7. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma
8. Anti proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
9. Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: Role of CD8+ T cells and IL-18
10. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
11. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
12. CpG oligodeoxynucleotides do not require Th1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
13. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway