Down-regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas

International Journal of Cancer

Volumn 89, Issue 3, 2000, Pages 213-216

  Yao, Jocelyn ^a   Eu, Kong Weng ^a   Seow Choen, Francis ^a   Cheah, Peh Yean ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P27;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SCORING SYSTEM; SINGAPORE;

AGE FACTORS; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE-FREE SURVIVAL; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM METASTASIS; SEX FACTORS; SINGAPORE; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033918737     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000520)89:3<213::AID-IJC1>3.0.CO;2-L     Document Type: Article

References (20)

1. AMERICAN JOINT COMMITTEE ON CANCER, IN O.H. BEAHRS, D.E. HENSON, R.V.P. HUTTER and B.J. KENNEDY (EDS.), Manual for staging of cancer. Lipppincott, New York (1992).
2. kip1 expression and progression of human esophageal squamous-cell carcinoma. Int. J. Cancer, 79, 439-443 (1998).
3. kip1 protein: Prognostic implications in primary breast cancer. Nature (Med.), 3, 227-230 (1997).
4. CHEAH, P.Y., CAO, X., EU, K.W. and SEOW, C.F., NM23-HI immunostaining is inversely associated with tumor staging but not overall survival or disease recurrence in colorectal carcinomas. Brit. J. Cancer, 77, 1164-1168 (1998).
5. CIAPARRONE, M., YAMAMOTO, H., YAO, Y., SGAMBATO, A., CATTORETTI, G., TOMITA, N., MONDEN, T., ROTTERDAM, H. and WEINSTEIN, I.B., Localization and expression of p27 kip1 in multistage colorectal carcinogenesis. Cancer Res., 58, 114-122 (1998).
6. DAHIA, P.L.M., AGUIAR, R.C.T., HONEGGAR, J., FAHLBUSH, R., JORDAN, S., LOWE, D.G., LU, X., CLAYTON, R.N., BESSER, G.M. and GROSSMAN, A.B., Mutation and expression analysis of the p27/kip1 gene in corticotrophinsecreting tumors. Oncogene, 16, 69-76 (1998).
7. ESPOSITO, V., BALDI, A., DE LUCA, A., GROGER, A.M., LODA, M., GIORDANO, G.G., CAPUTI, M., BALDI, F., PAGANO, M. and GIORDANO, A., Prognostic role of the cyclin-dependent kinase inhibitor p27 in non small-cell lung cancer. Cancer Res., 51, 3381-3385 (1997).
8. FANG, F., OREND, G., WATANABE, N., HUNTER, T. and RUOSLAHTI, E., Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science, 271, 499-502 (1996).
9. kip1 and degree of malignancy in human breast and colorectal cancers. Proc. nat. Acad. Sci. (Wash.), 94, 6380-6385 (1997).
10. LODA, M., CAKOR, B., TAM, S.W., LAVIN, P., FIORENTINO, M., DRAETTA, G.F., JESSUP, J.M. and PAGANO, M., Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nature (Med.), 3, 231-234 (1997).
11. MINETA, H., MIURA, K., SUZUKI, I., TAKEBAYASHI, S., AMANO, H., ARAKI, K., HARADA, H., ICHIMURA, K., WENNERBERG, J.P. and DICTOR, M.R., Low p27 expression correlates with poor prognosis for patients with oral tongue squamous-cell carcinoma. Cancer, 85, 1011-1017 (1999).
12. MORI, M., MIMORI, K., SHIRAISHI, T., TANAKA, S., UEO, H., SUGIMACHI, K. and AKIYOSHI, T., p27 expression and gastric carcinoma. Nature (Med.), 3, 593 (1997).
13. kip1 in anchorage-independent cells. Oncogene, 16, 2575-2583 (1998).
14. kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature (Med.), 3, 222-225 (1997).
15. STEEG, P. and ABRAMS, J.S., Cancer prognostics: Past, present and p27. Nature (Med.), 3, 152-154 (1997).
16. 1a,b) invasive breast carcinomas. Cancer Res., 51, 1259-1263 (1997).
17. THOMAS, G.V., SZIGETI, K., MURPHY, M., DRAETTA, G., PAGANO, M. and LODA, M., Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. Amer. J. Pathol., 153, 681-686 (1998).
18. YANG, R.M., NAITOH, J., MURPHY, M., WANG, H., PHILLIPSON, J., DEKERNION, J.B., LODA, M. and REITER, R.E., Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J. Urol., 159, 941-945 (1998).
19. kip1 is associated with advanced stage and invasiveness of gastric carcinomas. Jpn. J. Cancer Res., 88, 625-629 (1997).
20. kip1 in human lung cancers: Differential changes in small-cell and non-small-cell lung carcinomas. Cancer Res., 58, 1042-1047 (1998).