Apoptosis: Molecular regulation of cell death and hematologic malignancies

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 20, Issue 3, 2002, Pages 305-314

  Chiarugi, Vincenzo ^a   Cinelli, Marina ^a   Magnelli, Lucia ^a   Sbarba, Persio Dello ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Apoptosis; Hematologic malignancies

Indexed keywords

ASPARTIC ACID; CASPASE; CASPASE 9; CASPASE INHIBITOR; CYSTEINE PROTEINASE; CYTOCHROME C; GRANZYME B; LIPOCORTIN 5; PROTEIN BCL 2; PROTEINASE;

APOPTOSIS; CAENORHABDITIS ELEGANS; CELL DEATH; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SUBSTRATE; HEMATOLOGIC DISEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MOLECULAR INTERACTION; NICK END LABELING; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELL DEATH; DNA DAMAGE; FLOW CYTOMETRY; HEMATOLOGIC NEOPLASMS; HUMANS; IN SITU NICK-END LABELING; PROTEINS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 0036201155     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:20:3:305     Document Type: Review

References (50)

1. Apafl (CED-4 homolog) regulates programmed cell death in mammalian development
2. Cytochrome c and dATP-dependent formation of Apaf-l/caspase-9 complex initiates an apoptotic protease cascade
3. Apoptosis: Molecular regulation of cell death
4. The molecular biology of apoptosis
5. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
6. Mechanisms of functions of cell death
7. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
8. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
9. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
10. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII members of the ICE/CED-3 family of cysteine proteases
11. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
12. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
13. FADD/MORTI is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
14. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
15. Apoptosis by death factor
16. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
17. Fas ligand in human serum
18. Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor
19. Apoptosis
20. The role of apoptosis in antibody-dependent cellular cytotoxicity
21. Cloning and structural analysis of cDNAs for bcl-2 and hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
22. The pathogenesis of Burkitt's lymphoma
23. The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest
24. Burkitt's lymphoma cells are resistant to programmed cell death in the presence of the Epstein-Barr virus latent antigen EBNA-4
25. p53-mediated cell death: Relationship to cell cycle control
26. Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent cell line
27. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
28. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
29. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
30. Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome
31. The induction of apoptosis by chemoterapeutic agents occurs in all phases of the cell cycle
32. Apoptosis in the pathogenesis and treatment of disease
33. Activation-induced death by apoptosis in CD4+ T cells from human immuno-deficiency virus-infected asymptomatic individuals
34. Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-p53/K562 from apoptosis
35. Apoptosis induction in 32D cells by IL-3 withdrawal is preceded by a drop in the intracellular calcium level
36. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
37. Cytometry in cell necrobiology: Analisis of apoptosis and accidental cell death necrosis
38. Immunoassay for single-stranded DNA in apoptotic cells
39. Human neutrophils lose their surface Fc gamma Rill and acquire Annexin V binding sites during apoptosis in vitro
40. A DEVD-inhibited caspase other than CPP32 is involved in the committment of cerebellar granule neurons to apoptosis induced by K+ deprivation
41. Prodomains - Adaptors - Oligomerization: The pursuit of caspase activation in apoptosis
42. Caspases: Enemies within
43. Granzymes: Exogenous proteinases that induce target cell apoptosis
44. Characterization of the non-functional Fas ligand of gld mice
45. Melanoma cell expression of Fas (APO-1/CD95) ligand: Implications for tumor immune escape
46. Agonist antibody and Fas ligand mediate different sensitiviy to death in the signalling pathway of Fas and cytoplasmic mutants
47. Ceramide: An intracellular signal for apoptosis
48. Functions of ceramide in coordinating cellular responses to stress
49. Angiogenesis: A paradigm for balanced extracellular proteolysis during cell migration and morphogenesis
50. Macromolecular substrates for the ICE-like proteases during apoptosis