Evolution of viral quasispecies in four dominant HLA-A2 restricted T cell epitopes is not a major reason for viral persistence in interferon-treated patients with chronic hepatitis C

Journal of Medical Virology

Volumn 66, Issue 4, 2002, Pages 472-480

  Pingel, Sabine ^a   Weyer, Sandra ^a   Galle, Peter R ^a   Löhr, Hanns F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cellular immune responses; Cytotoxic T cells; Hepatitis C virus infection; Immune evasion; Viral complexity; Viral diversity

Indexed keywords

ALPHA INTERFERON; CORE PROTEIN; EPITOPE; HLA A2 ANTIGEN; RIBAVIRIN; T LYMPHOCYTE ANTIGEN; VIRUS ENVELOPE PROTEIN;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXIC T LYMPHOCYTE; DNA FLANKING REGION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GENETIC VARIABILITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOASSAY; IMMUNOTHERAPY; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERSISTENT VIRUS INFECTION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; VIRUS MUTATION; VIRUS STRAIN;

ADULT; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BASE SEQUENCE; EPITOPES, T-LYMPHOCYTE; EVOLUTION, MOLECULAR; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HLA-A2 ANTIGEN; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTES, CYTOTOXIC;

HEPATITIS C VIRUS;

EID: 0036198582     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.2168     Document Type: Article

References (26)

1. Patients with chronic hepatitis C have circulating cytotoxic T cells that recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
2. Presentation of viral antigen controlled by a gene in the major histocompatibility complex
3. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
4. Isolation of a cDNA clone derived from blood-borne non-A, non-B viral hepatitis genome
5. Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus
6. Treatment of chronic hepatitis C with recombinant interferon alpha. A multicenter randomized, controlled trial
7. Possible mechanism involving T lymphocyte response to NS3 in viral clearance in acute HCV infection
8. Hepatitis C virus after interferon treatment has the variation in the hypervariable region of envelope 2 gene
9. Evolution of viral quasispecies in interferon-treated patients with chronic hepatitis C virus infection
10. Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens
11. Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus and their relevance during the course of chronic infection
12. Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease
13. Virus escape from CTL recognition
14. Hepatitis C virus genome complexity correlates with response to interferon therapy: Study in French patients with chronic hepatitis C
15. CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained
16. The viral clearance in interferon-treated chronic hepatitis C is associated with increased cytotoxic T cell frequencies
17. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
18. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources
19. Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks vs. interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
20. Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
21. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
22. Randomised, double-blind, placebo-controlled trial of interferon α2b with and without ribavirin for chronic hepatitis C
23. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
24. Quasispecies nature of hepatitis C virus and response to alpha interferon: Significance as a predictor of direct response to interferon
25. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
26. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant