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Volumn 31, Issue 3, 1999, Pages 407-415

The viral clearance in interferon-treated chronic hepatitis C is associated with increased cytotoxic T cell frequencies

Author keywords

Cellular immune response; CTL frequency analysis; Cytotoxic T cells; ELISPOT; Hepatitis C virus; Interferon ; Viral clearance

Indexed keywords

CD8 ANTIGEN; HLA A2 ANTIGEN; HLA ANTIGEN CLASS 1; INTERFERON;

EID: 0033198353     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80030-0     Document Type: Article
Times cited : (57)

References (36)
  • 1
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of disease
    • Houghton M, Weiner A, Han J, Kuo G, Choo Q-L. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of disease. Hepatology. 14:1991;381-388.
    • (1991) Hepatology , vol.14 , pp. 381-388
    • Houghton M1    Weiner A2    Han J3    Kuo G4    Choo Q-L5
  • 2
    • 0027519138 scopus 로고
    • T-lymphocyte response to hepatitis C virus in different clinical courses of infection
    • Botarelli P, Brunetto MR, Minutello MA, Calvo P, Unutmaz D, Weiner AJ, et al. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology. 104:1993;580-587.
    • (1993) Gastroenterology , vol.104 , pp. 580-587
    • Botarelli P1    Brunetto MR2    Minutello MA3    Calvo P4    Unutmaz D5    Weiner AJ6
  • 3
    • 0027957464 scopus 로고
    • T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
    • Ferrari C, Valli A, Galati L, Penna A, Scaccaglia P, Giuberti T, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology. 19:1994;286-295.
    • (1994) Hepatology , vol.19 , pp. 286-295
    • Ferrari C1    Valli A2    Galati L3    Penna A4    Scaccaglia P5    Giuberti T6
  • 4
    • 0029739817 scopus 로고    scopus 로고
    • Liver-infiltrating and circulating CD4+ T cells in chronic hepatitis C: Immunodominant epitopes, HLA-restriction and functional significance
    • Löhr HF, Schlaak JF, Kollmannsperger S, Dienes HP, Meyer zum Büschenfelde KH, Gerken G. Liver-infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA-restriction and functional significance. Liver. 16:1996;174-182.
    • (1996) Liver , vol.16 , pp. 174-182
    • Löhr HF1    Schlaak JF2    Kollmannsperger S3    Dienes HP4    Meyer zum Büschenfelde KH5    Gerken G6
  • 5
    • 0027319205 scopus 로고
    • Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
    • Minutello MA, Pileri P, Unutmaz D, Censini S, Kuo G, Houghton M, et al. Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J Exp Med. 178:1993;17-25.
    • (1993) J Exp Med , vol.178 , pp. 17-25
    • Minutello MA1    Pileri P2    Unutmaz D3    Censini S4    Kuo G5    Houghton M6
  • 6
    • 0018753961 scopus 로고
    • MHC-restricted cytotoxic T cells. Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity
    • Zinkernagel RM, Doherty PC. MHC-restricted cytotoxic T cells. Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity. Adv Immunol. 19:1979;51-74.
    • (1979) Adv Immunol , vol.19 , pp. 51-74
    • Zinkernagel RM1    Doherty PC2
  • 7
    • 0026563173 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunisation with an engineered T-cytotoxic-T-helper synthetic peptide construct
    • Lasarte J-J, Sarobe P, Gullon A, Prieto J, Borras-Cuesta F. Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunisation with an engineered T-cytotoxic-T-helper synthetic peptide construct. Cell Immunol. 141:1996;211-218.
    • (1996) Cell Immunol , vol.141 , pp. 211-218
    • Lasarte J-J1    Sarobe P2    Gullon A3    Prieto J4    Borras-Cuesta F5
  • 8
    • 0028922525 scopus 로고
    • A helper T-cell antigen enhances generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro
    • Kita H, Moriyama T, Kaneko T, Hiroishi K, Harase I, Miura H, et al. A helper T-cell antigen enhances generation of hepatitis C virus-specific cytotoxic T lymphocytes in vitro. J Med Virol. 45:1995;386-391.
    • (1995) J Med Virol , vol.45 , pp. 386-391
    • Kita H1    Moriyama T2    Kaneko T3    Hiroishi K4    Harase I5    Miura H6
  • 9
    • 0030892283 scopus 로고    scopus 로고
    • Cytotoxic T cells and viral hepatitis
    • Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest. 99:1997;1472-1477.
    • (1997) J Clin Invest , vol.99 , pp. 1472-1477
    • Chisari FV1
  • 10
    • 0028962927 scopus 로고
    • Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
    • Battegay M, Fikes J, Di Bisceglie AM, Wentworth PA, Sette A, Celis E, et al. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol. 69:1995;2462-2470.
    • (1995) J Virol , vol.69 , pp. 2462-2470
    • Battegay M1    Fikes J2    Di Bisceglie AM3    Wentworth PA4    Sette A5    Celis E6
  • 11
    • 0028835980 scopus 로고
    • Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
    • Cerny A, McHutchison JG, Pasquinelli C, Brown ME, Brothers MA, Grabscheid B, et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest. 95:1995;521-530.
    • (1995) J Clin Invest , vol.95 , pp. 521-530
    • Cerny A1    McHutchison JG2    Pasquinelli C3    Brown ME4    Brothers MA5    Grabscheid B6
  • 12
    • 0027443147 scopus 로고
    • Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
    • Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, et al. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol. 67:1993;7522-7532.
    • (1993) J Virol , vol.67 , pp. 7522-7532
    • Koziel MJ1    Dudley D2    Afdhal N3    Choo QL4    Houghton M5    Ralston R6
  • 13
    • 0028832184 scopus 로고
    • HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release
    • Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, et al. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest. 96:1995;2311-2321.
    • (1995) J Clin Invest , vol.96 , pp. 2311-2321
    • Koziel MJ1    Dudley D2    Afdhal N3    Grakoui A4    Rice CM5    Choo QL6
  • 14
    • 0028912912 scopus 로고
    • CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1
    • Shirai M, Arichi T, Nishioka M, Nomura T, Ikeda K, Kawanishi K, et al. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1. J Immunol. 154:1995;2733-2742.
    • (1995) J Immunol , vol.154 , pp. 2733-2742
    • Shirai M1    Arichi T2    Nishioka M3    Nomura T4    Ikeda K5    Kawanishi K6
  • 15
    • 0029778817 scopus 로고    scopus 로고
    • Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
    • Rehermann B, Chang KM, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest. 98:1996;1432-1440.
    • (1996) J Clin Invest , vol.98 , pp. 1432-1440
    • Rehermann B1    Chang KM2    McHutchison JG3    Kokka R4    Houghton M5    Chisari FV6
  • 16
    • 0025968921 scopus 로고
    • Genetic organization and diversity of the hepatitis C virus
    • Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci USA. 88:1991;2451-2455.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2451-2455
    • Choo QL1    Richman KH2    Han JH3    Berger K4    Lee C5    Dong C6
  • 17
    • 0025855156 scopus 로고
    • Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
    • Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee H-G. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature. 351:1991;290-295.
    • (1991) Nature , vol.351 , pp. 290-295
    • Falk K1    Rötzschke O2    Stevanovic S3    Jung G4    Rammensee H-G5
  • 18
    • 0029953952 scopus 로고    scopus 로고
    • Detection and quantification of blood-derived CD8+ lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens
    • Herr W, Schneider J, Lohse AW, Meyer zum Büschenfelde K-H, Wölfel T. Detection and quantification of blood-derived CD8+ lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens. J Immunol Meth. 191:1996;131-146.
    • (1996) J Immunol Meth , vol.191 , pp. 131-146
    • Herr W1    Schneider J2    Lohse AW3    Meyer zum Büschenfelde K-H4    Wölfel T5
  • 19
    • 0021952907 scopus 로고
    • Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
    • Salter RD, Howell DN, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics. 21:1995;235-244.
    • (1995) Immunogenetics , vol.21 , pp. 235-244
    • Salter RD1    Howell DN2    Cresswell P3
  • 20
    • 0025284874 scopus 로고
    • Presentation of viral antigen controlled by a gene in the major histocompatibility complex
    • Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, Mc Michael A, et al. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature. 345:1990;449-454.
    • (1990) Nature , vol.345 , pp. 449-454
    • Cerundolo V1    Alexander J2    Anderson K3    Lamb C4    Cresswell P5    Mc Michael A6
  • 21
    • 0030934741 scopus 로고    scopus 로고
    • The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens
    • Herr W, Linn B, Leister N, Wandel E, Meyer zum Büschenfelde K-H, Wölfel T. The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens. J Immunol Meth. 203:1997;141-152.
    • (1997) J Immunol Meth , vol.203 , pp. 141-152
    • Herr W1    Linn B2    Leister N3    Wandel E4    Meyer zum Büschenfelde K-H5    Wölfel T6
  • 22
    • 0031794588 scopus 로고    scopus 로고
    • Quantitative and functional analysis of core-specific T helper cell and CTL activities in acute and chronic hepatitis B
    • Löhr HF, Krug S, Herr W, Weyer S, Schlaak J, Wölfel T, et al. Quantitative and functional analysis of core-specific T helper cell and CTL activities in acute and chronic hepatitis B. Liver. 18:1998;405-413.
    • (1998) Liver , vol.18 , pp. 405-413
    • Löhr HF1    Krug S2    Herr W3    Weyer S4    Schlaak J5    Wölfel T6
  • 23
    • 0030997098 scopus 로고    scopus 로고
    • Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment
    • Gerken G, Knolle P, Jakobs S, Meyer zum Büschenfelde K-H. Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment. Arch Virol. 142:1997;459-464.
    • (1997) Arch Virol , vol.142 , pp. 459-464
    • Gerken G1    Knolle P2    Jakobs S3    Meyer zum Büschenfelde K-H4
  • 24
    • 0027178527 scopus 로고
    • Typing of hepatitis C virus isolates and characterisation of new subtypes using a line probe assay
    • Stuyver L, Rossau R, Wyseur A, Dzuhamel LM, Vanderborght B, van Heuverswyn H, et al. Typing of hepatitis C virus isolates and characterisation of new subtypes using a line probe assay. J Gen Virol. 74:1993;1105-1113.
    • (1993) J Gen Virol , vol.74 , pp. 1105-1113
    • Stuyver L1    Rossau R2    Wyseur A3    Dzuhamel LM4    Vanderborght B5    Van Heuverswyn H6
  • 25
    • 0031068032 scopus 로고    scopus 로고
    • The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C
    • Nelson DR, Marousis CG, Davis GL, Rice CM, Wong J, Houghton M, et al. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J Immunol. 158:1997;1473-1481.
    • (1997) J Immunol , vol.158 , pp. 1473-1481
    • Nelson DR1    Marousis CG2    Davis GL3    Rice CM4    Wong J5    Houghton M6
  • 27
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
    • Murali-Krishna K, Altman JD, Suresh M, Sourdive DJD, Zajac AJ, Miller JD, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:1998;177-187.
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna K1    Altman JD2    Suresh M3    Sourdive DJD4    Zajac AJ5    Miller JD6
  • 28
    • 0028173126 scopus 로고
    • Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C
    • Appasamy R, Bryant J, Hassanein T, Van Thiel DH, Whiteside TL. Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C. Clin Immunol Immunopathol. 73:1994;350-357.
    • (1994) Clin Immunol Immunopathol , vol.73 , pp. 350-357
    • Appasamy R1    Bryant J2    Hassanein T3    Van Thiel DH4    Whiteside TL5
  • 29
    • 0031035147 scopus 로고    scopus 로고
    • HCV-RNA levelsplay an important role independently of genotype in predicting response to interferon therapy
    • Picciotto A, Campo N, Brizzolara R, Sinelli N, Poggi G, Grasso S, et al. HCV-RNA levelsplay an important role independently of genotype in predicting response to interferon therapy. Eur J Gastroenterol Hepatol. 9:1997;67-69.
    • (1997) Eur J Gastroenterol Hepatol , vol.9 , pp. 67-69
    • Picciotto A1    Campo N2    Brizzolara R3    Sinelli N4    Poggi G5    Grasso S6
  • 30
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet. 346:1995;1006-1007.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder HM1    Zachoval R2    Hoffmann RM3    Wierenga EA4    Santantonio T5    Jung MC6
  • 31
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity. 4:1996;35-36.
    • (1996) Immunity , vol.4 , pp. 35-36
    • Guidotti LG1    Ishikawa T2    Hobbs MV3    Matzke B4    Schreiber R5    Chisari FV6
  • 32
    • 0029558878 scopus 로고
    • Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes
    • Artini M, Nisini R, Missale G, Costanzo A, Accapezzato D, Balsano C, et al. Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes. Viral Immunol. 8:1995;63-73.
    • (1995) Viral Immunol , vol.8 , pp. 63-73
    • Artini M1    Nisini R2    Missale G3    Costanzo A4    Accapezzato D5    Balsano C6
  • 33
    • 0031030434 scopus 로고    scopus 로고
    • Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection
    • Fernandez I, Castellano G, Domingo MJ, Fuertes A, Colina F, Canga F, et al. Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection. Scand J Gastroenterol. 32:1997;70-76.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 70-76
    • Fernandez I1    Castellano G2    Domingo MJ3    Fuertes A4    Colina F5    Canga F6
  • 34
    • 0031043398 scopus 로고    scopus 로고
    • Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection
    • Hayashi J, Kishihara Y, Yamaji K, Furusyo N, Yamamoto T, Pae Y, et al. Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection. Hepatology. 25:1997;697-701.
    • (1997) Hepatology , vol.25 , pp. 697-701
    • Hayashi J1    Kishihara Y2    Yamaji K3    Furusyo N4    Yamamoto T5    Pae Y6
  • 35
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • Bertoletti A, Sette A, Chisari FV, Ferrari C. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature. 369:1994;407-410.
    • (1994) Nature , vol.369 , pp. 407-410
    • Bertoletti A1    Sette A2    Chisari FV3    Ferrari C4
  • 36
    • 0029421318 scopus 로고
    • Association of cytotoxic T lymphocyte (CTL) escape mutations with persistent hepatitis C virus (HCV) infection
    • Weiner AJ, Erickson AL, Kansopon J, Crawford K, Muchmore E, Houghton M, et al. Association of cytotoxic T lymphocyte (CTL) escape mutations with persistent hepatitis C virus (HCV) infection. Princess Takamatsu Symp. 25:1995;227-235.
    • (1995) Princess Takamatsu Symp , vol.25 , pp. 227-235
    • Weiner AJ1    Erickson AL2    Kansopon J3    Crawford K4    Muchmore E5    Houghton M6


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