The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: Role of cytochrome P4501B1

Cardiovascular Research

Volumn 53, Issue 4, 2002, Pages 1002-1009

  Moorthy, Bhagavatula ^a   Miller, Kimberly P ^b   Jiang, Weiwu ^a   Ramos, Kenneth S ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Atherosclerosis; Cell culture isolation; Free radicals; Signal transduction; Smooth muscle

Indexed keywords

1 ETHYNYLPYRENE; 3 METHYLCHOLANTHRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 INHIBITOR; DIMETHYL SULFOXIDE; DNA; OXYGENASE; PHOSPHORUS 32; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DNA ISOLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; FEMALE; GENOTOXICITY; ISOTOPE LABELING; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; ARYL HYDROCARBON HYDROXYLASES; BENZOPYRENE HYDROXYLASE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; PYRENES;

EID: 0036196883     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00536-3     Document Type: Article

References (52)

1. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function
2. Cigarette smoking, endothelial cell injury and cardiovascular disease
3. Environmental carcinogens
4. Carcinogenesis and atherogenesis differences in monooxygenase inducibility and bioactivation of benzo[a]pyrene in aortic and hepatic tissues of atherosclerosis-susceptible pigeons
5. Arteriosclerosis plaque development is 'promoted' by polynuclear aromatic hydrocarbons
6. Effects of 3-methylcholanthrene on atherosclerosis in two congenic strains of mice with different susceptibilities to methylcholanthrene-induced tumors
7. Effect of 3-methylcholanthrene on the development of aortic lesions in mice
8. Cancer biomarkers in human atherosclerotic lesions: Detection of DNA adducts
9. DNA adducts and chronic degenerative diseases. Pathogenic relevance and implications in preventive medicine
10. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
11. Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by downregulation of CYP1A1 gene expression in the rat hepatoma 5L cell line
12. The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachloro-p-dioxin and related compounds
13. DNA adducts, mutation, and cancer
14. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
15. Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures
16. In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer
17. Growth-related signaling as a target of toxic insult in vascular smooth muscle cells: Implications in atherogenesis
18. Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons
19. Induction of cytochrome CYP1A1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: A possible role in atherogenesis
20. Aryl-monooxygenase and cytochrome P450 in the aorta: Possible role in atherosclerosis
21. Induction of cytochrome P4501A1 by arylhydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells
22. Developmentally regulated cytochrome P4501A1 expression in cultured rat vascular smooth muscle cells
23. Modulation of aortic protein phosphorylation by benzo[a]pyrene: Implications in PAH-induced atherogenesis
24. Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: Role of aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism
25. Constitutive and inducible expression of cytochrome P4501A1 and P4501B1 in human vascular endothelial and smooth muscle cells
26. Activation of chemically diverse procarcinogens by human cytochrome P4501B1
27. Constitutive expression and induction of CYP1B1 mRNA in the mouse
28. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2
29. Dual regulation of cytochrome P450EF expression via the aryl hydrocarbon receptor and protein stabilization in C#H/10T1/2 cells
30. Stable expression of human cytochrome P4501B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a]pyrene
31. Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism
32. Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens
33. Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes: Evidence for catalytic activity and mRNA expression
34. Cytochrome P450 CYP1B1 protein expression: A novel mechanism of anticancer drug resistance
35. Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1
36. Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity
37. Aortic endothelial and smooth muscle cell cultures
38. Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture
39. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
40. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues
41. 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: Possible link between P450 turnover and formation of DNA adducts and I-compounds
42. 32P-postlabeling test for structurally diverse DNA adducts
43. Pentachlorophenol enhances 9-hydroxybenzo[a]pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: Likely inhibition of epoxide detoxication by pentachlorophenol
44. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules
45. The reaction of a 3-methylcholanthrene diol epoxide with DNA in relation to the binding of a 3-methylcholanthrene to the DNA of mammalian cells
46. Benzo[a]pyrene activates L1Md retrotransposon and inhibits DNA repair in vascular smooth muscle cells
47. Costitutive and inducible expression of CYP1A1 and CYP1B1 in vascular smooth muscle cells: Role of the AHR bHLH/PAS transcription factor
48. The possible involvement of somatic mutations in the development of atherosclerotic plaques
49. Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions
50. Protooncogene activation in spontaneously occurring and chemically-induced rodent and human lung tumors
51. Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors
52. Activation of c-Ha-ras by benzo[a]pyrene in vascular smooth muscle cells involves redox stress and aryl hydrocarbon receptor