MRI and fluorescence microscopy of the acute vascular response to VEGF165: Vasodilation, hyper-permeability and lymphatic uptake, followed by rapid inactivation of the growth factor

NMR in Biomedicine

Volumn 15, Issue 2, 2002, Pages 120-131

  Dafni, Hagit ^a   Landsman, Limor ^a   Schechter, Bilha ^a   Kohen, Fortune ^a   Neeman, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Albumin Gd DTPA; Angiogenesis; Contrast enhanced MRI; Interstitial colloid pressure; Lymphatics; VEGF

Indexed keywords

CAPILLARY FLOW; CELLS; FLUORESCENCE; MAGNETIC RESONANCE IMAGING; TUMORS;

VASCULAR PERMEABILITY;

BIOMEDICAL ENGINEERING;

BIOTIN; BOVINE SERUM ALBUMIN; CONTRAST MEDIUM; FLUORESCEIN ISOTHIOCYANATE; GADOLINIUM PENTETATE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VESSEL REACTIVITY; CONFOCAL MICROSCOPY; CONTRAST MEDIUM EXTRAVASATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RESPONSE; FLUORESCENCE MICROSCOPY; INTERSTITIUM; LYMPH VESSEL; MACROMOLECULE; MALE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; PARTITION COEFFICIENT; PLASMA; PRIORITY JOURNAL; TUMOR VASCULARIZATION; VASODILATATION;

ANIMALS; CONTRAST MEDIA; ENDOTHELIAL GROWTH FACTORS; GADOLINIUM DTPA; LYMPHOKINES; MAGNETIC RESONANCE IMAGING; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; PROTEIN ISOFORMS; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VASODILATION;

MUS MUSCULUS;

EID: 0036194973     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.724     Document Type: Article

References (34)

1. Vascular endothelial growth factor and the regulation of angiogenesis
2. In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: Magnetic resonance imaging of C6 rat glioma in nude mice
3. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
4. Vascular permeability factor (VPF, VEGF) in tumor biology
5. Tumor angiogenesis and interstitial hypertension
6. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
7. Flow velocity in the superficial lymphatic network of the mouse tail
8. Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation
9. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
10. Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo
11. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
12. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
13. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas
14. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
15. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
16. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: Preparation and characterization
17. Spectrophotometric determination of avidin and biotin
18. In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: Validation by intravital microscopy
19. Histologic confirmation of microvascular hyperpermeability to macromolecular MR contrast medium in reperfused myocardial infarction
20. Angiogenesis imaging
21. Evaluation of tumor angiogenesis with US: Imaging, Doppler, and contrast agents
22. In vivo monitoring of tumor angiogenesis with MR imaging
23. Tumor angiogenesis: Molecular pathology, therapeutic targeting, and imaging
24. The VEGF splice variants: Properties, receptors, and usage for the treatment of ischemic diseases
25. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
26. A novel function of VEGF receptor-2 (KDR): Rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells
27. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
28. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
29. Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium
30. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
31. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
32. VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells
33. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization