Crystal structure of the GABAA-receptor-associated protein, GABARAP

EMBO Reports

Volumn 3, Issue 2, 2002, Pages 183-189

  Bavro, Vassiliy N ^a   Sola, Maria ^a   Bracher, Andreas ^a   Kneussel, Matthias ^b   Betz, Heinrich ^c   Weissenhorn, Winfried ^d  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ASSOCIATED PROTEIN; CELL MEMBRANE PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; N ETHYLMALEIMIDE; RECEPTOR SUBUNIT; TUBULIN; UBIQUITIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; INTRACELLULAR MEMBRANE; MICROTUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RAT; SEQUENCE HOMOLOGY; TRANS GOLGI NETWORK; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, GABA-A;

MAMMALIA;

EID: 0036193182     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf026     Document Type: Article

References (41)

1. The CCP4 suite: Programs for protein crystallography
2. The γ-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics
3. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
4. Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
5. Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity
6. The 4 Å X-ray structure of a tubulin:stathmin-like domain complex
7. The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways
8. A ubiquitin-like system mediates protein lipidation
9. Membrane fusion and exocytosis
10. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
11. Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex
12. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
13. The 93-kDa glycine receptor-associated protein binds to tubulin
14. The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors
15. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice
16. The γ-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
17. The X-ray crystal structure and putative ligand-derived peptide-binding properties of GABAA receptor associated protein (GABARAP)
18. Molscript: A program to produce both detailed and schematic plots of protein structure
19. Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole
20. PROCHECK: A program to check the stereochemical quality of protein structures
21. Isolation and characterization of a novel low molecular weight protein involved in intra-Golgi traffic
22. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B
23. Constructing inhibitory synapses
24. SCOP: A structural classification of proteins database for the investigation of sequences and structures
25. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
26. Structural insights into microtubule function
27. Protein superfamilies and domain superfolds
28. Processing of X-ray data collected in oscillation mode
29. Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p
30. Automated protein model building combined with iterative structure refinement
31. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein
32. TURBO. In Silicon Graphics
33. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28
34. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy
35. The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
36. WHAT IF: A molecular modeling and drug design program
37. Model for stathmin/OP18 binding to tubulin
38. Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction
39. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton
40. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein