Sulfonylurea receptor -1 (SUR1): Genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus

Diabetes and Metabolism

Volumn 28, Issue 1, 2002, Pages 14-19

  Reis, A F ^a   Velho, G ^a  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

Author keywords

ATP sensitive potassium channel; Genetics; Insulin secretion; Sulfonylurea receptor; Type 2 diabetes mellitus

Indexed keywords

ION CHANNEL; RECEPTOR SUBTYPE; SULFONYLUREA; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR;

CHANNEL GATING; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; SHORT SURVEY;

ATP-BINDING CASSETTE TRANSPORTERS; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS; VARIATION (GENETICS);

EID: 0036181028     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (29)

1. Molecular biology of adenosine triphosphate-sensitive potassium channels
2. ATP-sensitive K+ channels and insulin secretion: Their role in health and disease
3. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties
4. Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K-ATP channels
5. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
6. Mutation of the pancreatic islet inward rectifier kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy
7. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in caucasians
8. Variants in the sulfonylurea receptor gene: Association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians
9. Sulfonylurea receptor-1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
10. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene
11. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
12. Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: A population study
13. Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians
14. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene
15. Identification of micro-satellite markers near the human genes encoding the beta-cell ATP-Sensitive k+ channel and linkage studies with NIDDM in Japanese
16. Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM
17. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)
18. Genetic variability of the SUR1 promoter in relation to beta-cell function and Type 2 diabetes mellitus
19. Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): A meta-analysis suggest a role in the polygenic basis of type II diabetes mellitus in Caucasians
20. Sequence variations in the human kir6.2 gene, a subunit of the beta-cell ATP-sensitive k-channel: No association with NIDDM in white caucasian subjects or evidence of abnormal function when expressed in vitro
21. Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with type II diabetes mellitus
22. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: The sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor I alpha genes
23. Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
24. Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia
25. Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM
26. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice
27. Reduced beta-cell function and blood pressure in carriers of intron 16-3t variant of the sulfonylurea receptor gene
28. SUR1 Knockout mice. A model for KATP channel-independent regulation of insulin secretion
29. Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel