Nucleic acid molecular biomarkers for diagnostic biodosimetry applications: Use of the fluorogenic 5′-nuclease polymerase chain reaction assay

Military Medicine

Volumn 167, Issue 2 SUPPL., 2002, Pages 16-19

  Blakely, William F ^a   Miller, Alexandra C ^a   Luo, Lei ^a   Lukas, Jason ^a   Hornby, Zachary D ^a   Hamel, Christine J C ^a   Nelson, Joseph T ^a   Escalada, Nestor E ^a   Prasanna, Pataje G S ^a  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENTARY DNA; NUCLEASE; NUCLEIC ACID;

CONFERENCE PAPER; DIAGNOSTIC VALUE; DOSE RESPONSE; FLUORESCENCE; GENE EXPRESSION; GENE TARGETING; HUMAN; IONIZING RADIATION; MILITARY PHENOMENA; NUCLEIC ACID ANALYSIS; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY;

EID: 0036176878     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.1093/milmed/167.suppl_1.16     Document Type: Conference Paper

References (21)

1. Biological dosimetry: Chromosomal aberrations analysis for dose assessment
2. Development of rapid biodosimetry capability: Use of cytogenetic and molecular biomarkers
3. Detection of specific polymerase chain reaction product by utilizing the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase
4. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
5. Real time quantitative PCR
6. PCR detection of bacteria in seven minutes
7. Rapid pathogen detection using a microchip PCR array instrument
8. Multiple endpoints for somatic mutations in humans provide complementary views for biodosimetry, genotoxicity and health risks
9. Digital PCR
10. A dose response for radiation-induced intrachromosomal DNA rearrangements detected by inverse polymerase chain reaction
11. Induction of a particular deletion in mitochondrial DNA by x-rays depends on the inherent radiosensitivity of the cells
12. Radiation induction of the "common" mitochondria DNA deletion in in vitro exposed human lymphocytes: Use of in situ PCR assay
13. Biological dosimetry using interphase human peripheral blood lymphocytes: Proceedings of the International Conference on low-level radiation injury and medical countermeasures
14. Potential molecular targets for manipulating the radiation response
15. Cellular proto-oncogene expression following exposure of mice to gamma rays
16. Protooncogene expression: A predictive assay for biodosimetry applications
17. Ras proto-oncogene expression and protein production: A predictive assay for biodosimetry applications
18. Induction of interleukin 6 by ionizing radiation in a human epithelial cell line: Control by corticosteroids
19. Application of the premature chromosome condensation assay in simulated partial-body radiation exposures: Evaluation of the use of an automated metaphase-finder
20. Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione