VSP417-6, a variant-specific surface protein encoded at a sixth locus within the vsp417 gene subfamily of Giardia intestinalis

International Journal for Parasitology

Volumn 32, Issue 4, 2002, Pages 425-436

  Ey, Peter L ^a   Darby, Jocelyn M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Antigenic variation; Evolution; Gene families; Protozoa

Indexed keywords

MEMBRANE PROTEIN; POLYPEPTIDE;

PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA PROBE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE SEQUENCE; GENETIC CODE; GENOTYPE; GIARDIA LAMBLIA; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PHYLOGENY; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENIC VARIATION; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; EVOLUTION, MOLECULAR; GENES, PROTOZOAN; GIARDIA LAMBLIA; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PROTOZOAN PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA;

GIARDIA; GIARDIA INTESTINALIS; PROTOZOA;

EID: 0036176533     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(01)00366-6     Document Type: Article

References (47)

1. The biology of Giardia spp.
2. Antigenic variation of a cysteine-rich protein in Giardia lamblia
3. The cysteine-rich protein gene family of Giardia lamblia: Loss of the CRP170 gene in an antigenic variant
4. Giardia lamblia: Post-translational processing and status of exposed cysteine residues in TSA 417, a variable surface antigen
5. Basic local alignment search tool
6. Giardia intestinalis: Electrophoretic evidence for a species complex
7. Antigenic variation in trypanosomes
8. A new cysteine-rich protein-encoding gene family in Giardia duodenalis
9. Giardia intestinalis: Conservation of the variant-specific surface protein VSP417-1 (TSA417) and identification of a divergent homologue encoded at a duplicated locus in genetic Group II isolates
10. Differentiation of major genotypes of Giardia intestinalis by polymerase chain reaction analysis of a gene encoding a trophozoite surface antigen
11. Giardia intestinalis: Detection of major genotypes by restriction analysis of gene amplification products
12. A gene encoding a 69-kilodalton major surface protein of Giardia intestinalis trophozoites
13. Comparison of genetic groups determined by molecular and immunological analyses of Giardia isolated from animals and humans in Switzerland and Australia
14. Genetic analysis of Giardia from hoofed farm animals reveals artiodactyl-specific and potentially zoonotic genotypes
15. Comparison of tsa417-like variant-specific surface protein (VSP) genes in Giardia intestinalis and identification of a novel locus in genetic Group II isolates
16. A new locus (vsp417-4) belonging to the tsa417-like subfamily of variant-specific surface protein genes in Giardia intestinalis
17. Isolation and expression of the gene for a major surface protein of Giardia lamblia
18. Cellular and transcriptional changes during excystation of Giardia lamblia in vitro
19. Comparison of Giardia isolates from different laboratories by isoenzyme analysis and recombinant DNA probes
20. In situ analyses reveal that the two nuclei of Giardia lamblia are equivalent
21. MEGA: Molecular evolutionary genetics analysis software for microcomputers
22. Detection of Giardia trophozoites in archival pathology specimens of human small intestine
23. The Giardia genome project database
24. Division of Giardia isolates from humans into two genetically distinct assemblages by electrophoretic analysis of enzymes encoded at 27 loci and comparison with Giardia muris
25. Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia
26. Molecular genetic analysis of Giardia intestinalis isolates at the glutamate dehydrogenase locus
27. Molecular systematics of the parasitic protozoan Giardia intestinalis
28. Carboxy-terminal sequence conservation among variant-specific surface proteins of Giardia lamblia
29. Size heterogeneity among antigenically related Giardia lamblia variant-specific surface proteins is due to differences in tandem repeat copy number
30. Periodic appearance of a predominant variant antigen type during a chronic Giardia lamblia infection in a mouse model
31. Surface antigen variability and variation in Giardia lamblia
32. Characterization of a Giardia lamblia variant-specific surface protein (VSP) gene from isolate GS/M and estimation of the VSP gene repertoire size
33. Antigenic variation in Giardia lamblia
34. Frequency of variant antigens in Giardia lamblia
35. Giardia lamblia: Identification and characterization of a variant-specific surface protein gene family
36. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
37. TREEVIEW: An application to display phylogenetic trees on personal computers
38. The release of the variant-specific surface protein of Giardia to its soluble isoform is mediated by selective cleavage of the conserved carboxy-terminal domain
39. Primary structure and biochemical properties of a variant-specific surface protein of Giardia
40. Improved tools for biological sequence comparison
41. Biological selection of variant-specific surface proteins in Giardia lamblia
42. A hidden Markov model for predicting transmembrane helices in protein sequences
43. Differentiation-associated surface antigen variation in the ancient eukaryote Giardia lamblia
44. The course of giardiavirus infection in the Giardia lamblia trophozoites
45. CLUSTAL W - Improving the sensitivity of progressive multiple alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
46. Analysis of a repeat-containing family of Giardia lamblia variant-specific surface protein genes: Diversity through duplication and divergence
47. Giardia lamblia trophozoites contain multiple alleles of a variant surface protein gene containing a 105-base pair tandem repeat