LcrQ and SycH function together at the Ysc type III secretion system in Yersinia pestis to impose a hierarchy of secretion

Molecular Microbiology

Volumn 43, Issue 2, 2002, Pages 411-423

  Wulff Strobel, Christine R ^a   Williams, Andrew W ^a,b   Straley, Susan C ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b McDonnell Boehnen Hulbert and Berghoff LLP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHAPERONE; PROTEIN LCRG; PROTEIN LCRQ; PROTEIN LCRV; PROTEIN SYCH; REGULATOR PROTEIN; UNCLASSIFIED DRUG; YERSENIA OUTER PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TRANSPORT; YERSINIA PESTIS;

ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; GENE EXPRESSION; MOLECULAR CHAPERONES; MUTAGENESIS; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; YERSINIA PESTIS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; YERSINIA; YERSINIA ENTEROCOLITICA; YERSINIA PESTIS; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0036170459     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02752.x     Document Type: Article

References (43)

1. Mutational analysis of the Yersinia enterocolitica virC operon: Characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR
2. Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
3. LcrQ/YscM1, regulators of the Yersinia yop virulon, are injected into host cells by a chaperone-dependent mechanism
4. 28 domain
5. TheYersinia deadly kiss
6. Assembly and function of type III secretory systems
7. Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genes
8. Virulence role of V antigen of Yersinia pestis at the bacterial surface
9. The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis
10. The chaperone-like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensable for targeting to the secretion loci
11. Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments
12. The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton
13. LcrV is a channel size-determining component of the Yop effector translocon of Yersinia
14. Type III protein secretion systems in bacterial pathogens of animals and plants
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu
17. Conditionally replicative and conjugative plasmids carrying lacZa for cloning, mutagene-sis, and allele replacement in bacteria
18. A novel suicide vector and its use in construction of insertion mutations: Osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR
19. Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
20. Phylogenetic analyses of the constituents of type III protein secretion systems
21. The V antigen ofYersinia pestis regulates Yop vectoral targeting as well as Yop secretion through effects of YopB and LcrG
22. Yersinia pestisetiologic agent of plague
23. 2+-response plasmid pCD1 of Yersinia pestis KIM5
24. Modulation of virulence factor expression by pathogen target cell contact
25. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
26. Multiple effects of lcrD mutations in Yersinia pestis
27. Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis
28. Detection and characterization ofYersinia pestis plasmids determining pesticin I, fraction I antigen and mouse toxin synthesis
29. A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH
30. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
31. Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae
32. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
33. LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis
34. Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis
35. YscM1 and YscM2, two Yersinia enterocolitica proteins causing down-regulation of yop transcription
36. 2+ in Yersinia pestis include structural genes for outer membrane proteins
37. Yersinia: Strategies that thwart immune defenses
38. Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
39. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
40. r phenotypes of yersiniae
41. YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of yops
42. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene