Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides

Journal of Reproductive Immunology

Volumn 54, Issue 1-2, 2002, Pages 93-115

  Deng, X ^a   Meyers, S A ^b   Tollner, T L ^a   Yudin, A I ^a   Primakoff, P D ^a   He, D N ^a   Overstreet, J W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Contraception; Immunization; Macaque; PH 20; Sperm

Indexed keywords

AMINO ACID; ANTIBODY; CONTRACEPTIVE VACCINE; DIETHYLSTILBESTROL; IMMUNOLOGICAL ADJUVANT; LYSINE; MONTANIDE ISA 51; MULTIPLE ANTIGENIC PEPTIDE MATRIX; PEPTIDE 4; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PROTEIN DERIVATIVE; PROTEIN E10; PROTEIN G18; PROTEIN PH 20; QS 21; RECOMBINANT PROTEIN; TETANUS TOXOID; TITERMAX GOLD; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; GENE CONSTRUCT; IMMUNIZATION; IMMUNOCONTRACEPTION; IMMUNOFLUORESCENCE; INFLAMMATION; MACACA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TARGETING; WESTERN BLOTTING;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CONTRACEPTION; FEMALE; HYALURONOGLUCOSAMINIDASE; IMMUNIZATION; MACACA FASCICULARIS; MALE; MOLECULAR SEQUENCE DATA; POLOXALENE; POLYSORBATES; RECOMBINANT PROTEINS; SAPONINS; SQUALENE;

EID: 0036169661     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0378(01)00124-3     Document Type: Article

References (57)

1. Immunopotentiation and the selective induction of immune responses
2. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity
3. Adjuvants
4. The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin
5. Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies
6. The PH-20 protein in Cynomolgus macaque spermatozoa: Identification of two different forms exhibiting hyaluronidase activity
7. Hyaluronic acid and the cumulus extracellular matrix induce increases in intracellular calcium in macaque sperm via the plasma membrane protein PH-20
8. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31
9. The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes
10. Mouse Spam1 (PH-20): Evidence for its expression in the epididymis and for a new category of spermatogenic-expressed genes
11. Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: Clinical evaluation of a phase I-II trial
12. Expression and activity of articular cartilage hyaluronidases
13. The potential use of sperm antigens as targets for immunocontraception; past, present and future
14. The mode of action of immunological adjuvants
15. Purification, cloning, and expression of human plasma hyaluronidase
16. Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm
17. Adjuvants - A balance between toxicity and adjuvanticity
18. Identification of two promiscuous T cell epitopes from tetanus toxin
19. Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81
20. Structural relationship of sperm soluble hyaluronidase to the sperm membrane protein PH-20
21. The adjuvant activity of nonionic block polymer surfactants. II. Antibody formation and inflammation related to the structure of triblock and octablock copolymers
22. Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes
23. Comparative efficacy of experimental anthrax vaccine candidates against inhalation anthrax in rhesus macaques
24. Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies
25. QS-21: A water-soluble triterpene glycoside adjuvant
26. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
27. Hyaluronidases - A group of neglected enzymes
28. Oviductal antibody response to a defined recombinant sperm antigen in macques
29. Immune response to immunization with sperm antigens in the macaque oviduct
30. Synthetic immunomodulators and synthetic vaccines
31. Biochemical characterization of the PH-20 protein on the plasma membrane and inner acrosomal membrane of Cynomolgus macaque spermatozoa
32. Molecular cloning of the human and monkey sperm surface protein PH-20
33. A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
34. Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside - Keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma
35. Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine
36. Hyaluronidase activity of macaque sperm assessed by an in vitro cumulus penetration assay
37. Induction of antigen-specific killer T lymphocyte responses using subunit SIVmac251 gag and env vaccines containing QS-21 saponin adjuvant
38. Reversible contraception in female baboons immunized with a synthetic epitope of sperm-specific lactate dehydrogenase
39. Colinear synthesis of an antigen-specific B-cell epitope with a 'promiscuous' tetanus toxin T-cell epitope: A synthetic peptide immunocontraceptive
40. Immune responses induced by prototype vaccines for AIDS in rhesus monkeys
41. Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques
42. Assays for adjuvanticity of new formulations and of carrier proteins for inducing antibody responses to selected immunogens in the squirrel monkey Saimiri sciureus
43. HIV-specific immunity following immunization with HIV synthetic envelope peptides in asymptomatic HIV-infected patients
44. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20
45. Modulation of humoral and cell-mediated immune responses by a structurally established nontoxic lipid A
46. High-titer HIV-1 neutralizing antibody response of rhesus macaques to gp160 and env peptides
47. Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system
48. The PH-20 protein in human spermatozoa
49. The use of nonmetal electrodes in electroejaculation of restrained but unanesthetized macaques
50. Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli
51. Oral immunization with attenuated Salmonella expressing human sperm antigen induces antibodies in serum and the reproductive tract
52. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase
53. Soybean trypsin inhibitor as a probe for the acrosome reaction in motile cynomolgus macaque sperm
54. Monophosphoryl lipid A as an adjuvant. Past experiences and new directions
55. Expression of foreign proteins in E. coli using plasmid vectors and purification of specific polyclonal antibodies
56. PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida