Fibroblast growth factors and their receptors in hematopoiesis and hematological tumors

Journal of Hematotherapy and Stem Cell Research

Volumn 11, Issue 1, 2002, Pages 19-32

  Moroni, Emanuela ^a   Dell'Era, Patrizia ^a   Rusnati, Marco ^a   Presta, Marco ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; PROTEOHEPARAN SULFATE; TYROSINE KINASE RECEPTOR;

ACCESSORY CELL; AUTOCRINE EFFECT; BLOOD DYSCRASIA; BONE MARROW CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MOTILITY; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; CELL TYPE; ENDOTHELIUM CELL; HEMATOPOIESIS; HUMAN; MESODERM; NEUROECTODERM; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; STROMA CELL; ANIMAL; BLOOD DISEASE; CYTOLOGY; DRUG EFFECT; GENETICS; HEMATOPOIETIC STEM CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; FIBROBLAST GROWTH FACTORS; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 0036168515     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581602753448513     Document Type: Review

References (172)

1. Fibroblast growth factors
2. The FGF family of growth factors and oncogenes
3. Crystal structure of basic fibroblast growth factor at 1.6 A resolution
4. Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta
5. A dual receptor system is required for basic fibroblast growth factor activity
6. FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos
7. mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation
8. Mesoderm-inducing properties of INT-2 and kFGF: Two oncogene-encoded growth factors related to FGF
9. Targeted disruption of Fgf 8 causes failure of cell migration in the gastrulating mouse embryo
10. Requirement of FGF-4 for postimplantation mouse development
11. Fibroblast growth factors in the developing central nervous system
12. Fgf10 is essential for limb and lung formation
13. Fibroblast growth factors induce additional limb development from the flank of chick embryos
14. An additional limb can be induced from the flank of the chick embryo by FGF4
15. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development
16. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
17. The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
18. The roles of FGFs in the early development of vertebrate limbs
19. Angiogenesis in cancer and other diseases
20. Mechanisms of angiogenesis and arteriogenesis
21. Fibroblast growth factors, their receptors and signaling
22. Target molecules for anti-angiogenic therapy: From basic research to clinical trials
23. Signal transduction by receptors with tyrosine kinase activity
24. Signalling by receptor tyrosine kinases
25. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
26. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
27. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3
28. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern
29. The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain
30. Structural and functional diversity in the FGF receptor multigene family
31. A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III
32. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
33. Receptor specificity of the fibroblast growth factor family
34. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
35. Proteins with SH2 domains: Transducers in the tyrosine kinase signaling pathway
36. SH2 and SH3 domains
37. PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine
38. Protein modules and signalling networks
39. SH2 and PTB domain interactions in tyrosine kinase signal transductionn
40. Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin
41. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
42. Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
43. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (flg) is a binding site for the SH2 domain of phospholipase C-γ1
44. Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
45. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
46. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
47. Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells
48. Different tyrosine autophosphorylation requirements in fibroblast growth factor receptor-1 mediate urokinase-type plasminogen activator induction and mitogenesis
49. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
50. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
51. Function of cell surface heparan sulfate proteoglycans
52. Heparan sulfate proteoglycans: Intricate molecules with intriguing functions
53. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
54. Identification of glypican as a dual modulator of the biological activity of fibroblast growth factors
55. Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ
56. Interaction of angiogenic basic fibroblast growth factor with endothelial cell heparan sulfate proteoglycans: Biological implications in neovascularization
57. Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form
58. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
59. Developmental biology of hematopoiesis
60. Recent advances in the growth and isolation of primitive human hematopoietic progenitors cells
61. Mouse hematopoietic stem cells
62. Mouse embryonic hematopoiesis
63. Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors
64. Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus
65. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembrionic splanchnopleura
66. An early pre-liver embryonic source of CFU-S in the developing mouse
67. Definitive hematopoiesis is autonomously initiated by the AGM region
68. Development of hematopoietic stem cell activity in the mouse embryo
69. The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis
70. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo
71. The T-cell leukemia oncoportein SCL/tal-1 is essential for development of all hematopoietic lineages
72. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis
73. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription GATA-1
74. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
75. An early hematopoietic defect in mice lacking the transcription factor GATA-2
76. The human hematopoietic colony-stimulating factors
77. Differentiation and proliferation of hematopoietic stem cells
78. Hematopoietic cell growth factors and their receptors
79. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos
80. Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification
81. Opposite effects of FGF and BMP-4 on embryonic blood formation: Roles of PV. 1 and GATA-2
82. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells
83. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate
84. BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix. 1
85. Expression of GATA-binding proteins during embryonic development in Xenopus laevis
86. Xom: A Xenopus homeobox gene that mediates the early effects of BMP-4
87. Differential regulation of neurogenesis by the two Xenopus GATA-1 genes
88. BMP-like signals are required after the midblastula transition for blood cell development
89. Regulation of the fibroblast growth factor receptor in early Xenopus embryos
90. Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm
91. Involvement of the MAP kinase in Xenopus mesoderm induction
92. Basic fibroblast growth factor positively regulates hematopoietic development
93. The embryonic origins of human haematopoiesis
94. The role of fibroblast growth factor-2 (FGF-2) in hematopoiesis
95. The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation
96. Cellular distribution of platelet-derived growth factor, transforming growth factor-beta, basic fibroblast growth factor, and their receptors in normal bone marrow
97. Interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis and demonstration of FGF receptor expression in megakaryocytes and megakaryocytic-like cells
98. Effect of basic (FGF-2) and acidic (FGF-1) fibroblast growth factors on early haemopoietic cell development
99. Basic fibroblast growth factor mediates its effects on committed myeloid progenitors by direct action and has no effect on hematopoietic stem cells
100. Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors
101. Bone marrow stromal cell distribution of basic fibroblast growth factor in chronic myeloid disorders
102. Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells
103. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner
104. An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures
105. Regulation of proteolytic activity in human bone marrow stromal cells by basic fibroblast growth factor, interleukin-1, and transforming growth factor beta
106. Enhanced growth of megakaryocyte colonies in culture in the presence of heparin and fibroblast growth factor
107. Acidic fibroblast growth factor (FGF1) increases survival and haematopoietic recovery in total body irradiated C3H/HeNCr mice
108. Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
109. Keratinocyte growth factors radioprotect bowel and bone marrow but not kht sarcoma
110. Stimulation of thrombopoiesis in mice by fibroblast growth factor 9
111. Adenovirus-mediated transfer of the HST-1 (FGF4) gene induces increased levels of platelet count in vivo
112. Basic fibroblast growth factor and epidermal growth factor downmodulate the growth of hematopoietic cells in long-term stromal cultures
113. Long-term culture of human bone marrow stromal cells in the presence of basic fibroblast growth factor
114. Control of stroma-dependent hematopoiesis by basic fibroblast growth factor: Stromal phenotypic plasticity and modified myelopoietic functions
115. Effects of fibroblast growth factor-4 (k-FGF) on long-term cultures of human bone marrow cells
116. Activation of extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: Differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells
117. Human mesenchymal stem cells respond to fibroblast growth factors
118. Self-renewal and differentiation of a basic fibroblast growth factor-dependent multipotent hematopoietic cell line derived from embryonic stem cells
119. "Pure" human hematopoietic progenitors: Permissive action of basic fibroblast growth factor
120. Basic fibroblast growth factor (B-FGF) induces early- (CFU-s) and late-stage hematopoieticprogenitor cell colony formation (CFU-gm, CFU-meg, and BFU-e) by synergizing with GM-CSF, Meg-CSF, and erythropoietin, and is a radioprotective agent in vitro
121. Basic fibroblast growth factor promotes the proliferation of human megakaryocyte progenitor cells
122. Basic fibroblast growth factor counteracts the suppressive effect of transforming growth factor-beta 1 on human myeloid progenitor cells
123. Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells
124. Stem cell factor and basic fibroblast growth factor are synergistic in augmenting committed myeloid progenitor cell growth
125. Basic fibroblast growth factor stimulates myelopoiesis in long-term human bone marrow cultures
126. The MS-5 murine stromal cell line and hematopoietic growth factors synergize to support the megakaryocytic differentiation of embryonic stem cells
127. Hematopoietic regulators: Redundancy or subtlety?
128. Biological roles of fibroblast growth factor-2
129. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor
130. Expression of B cell markers on SR-4987 cells derived from murine bone marrow stroma
131. Expression of fibroblast growth factor receptors in human leukemia cells
132. Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells
133. Expression of basic fibroblast growth factor (bFGF) and FGF-receptors in human leukemic cells
134. Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: Downmodulation of FGF receptors by phorbol ester
135. FGFR1 and MOZ, two key genes involved in malignant hemopathies linked to rearrangements within the chromosomal region 8p11-12
136. ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain
137. 8p12 Stem Cell Myeloproliferative Disorder: The FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways
138. A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4
139. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: The achondroplasia family of skeletal dysplasias. Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans
140. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
141. A novel chromosomal translocation t(4;14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
142. FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma
143. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
144. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
145. Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain
146. Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
147. The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
148. Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
149. Avian monocytic leukemia cells release fibroblast growth factor: Implications to associated myelofibrosis
150. Constitutive and selective expression of basic fibroblast growth factor in human leukaemia cell lines
151. Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis
152. Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization
153. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers
154. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
155. FGF-2 abnormalities in B cell chronic lymphocytic and chronic myeloid leukemias
156. Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine
157. Basic fibroblast growth factor is expressed by CD19/CD11c-positive cells in hairy cell leukemia
158. Bcl-2 expression correlates positively with serum basic fibroblast growth factor (bFGF) and negatively with cellular vascular endothelial growth factor (VEGF) in patients with chronic lymphocytic leukaemia
159. Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis
160. Synergistic effects of basic fibroblast growth factor and hematopoietic growth factors on colony formation of K562 human leukemic cells
161. The effect of basic and acidic fibroblast growth factors (bFGF and aFGF) on the growth of leukemic blast progenitors in acute myelogenous leukemia
162. Bone marrow neovascularization, plasma cell angiogenic potential and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
163. Angiogenesis in acute and chronic leukemias and myelodisplastic syndromes
164. Evidence of increased angiogenesis in patients with acute myeloid leukemia
165. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
166. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia
167. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
168. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo
169. Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors
170. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis
171. Antiangiogenesis is produced by nontoxic doses of vinblastine