Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulation

Experimental Brain Research

Volumn 135, Issue 3, 2000, Pages 293-299

  Schwenkreis, P ^a   Liepert, J ^a   Witscher, K ^a   Fischer, W ^a   Weiller, C ^a   Malin, J P ^a   Tegenthoff, M ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Human; Intracortical facilitation; Intracortical inhibition; Riluzole; Transcranial magnetic stimulation

Indexed keywords

GLUTAMATE RECEPTOR ANTAGONIST; RILUZOLE;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTROPHYSIOLOGY; FACILITATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR ACTIVITY; MOTOR CORTEX; NERVE STIMULATION; NORMAL HUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; DEPRESSION, CHEMICAL; ELECTROMAGNETIC FIELDS; ELECTROPHYSIOLOGY; EVOKED POTENTIALS, MOTOR; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; MOTOR CORTEX; PERIPHERAL NERVOUS SYSTEM; RILUZOLE;

EID: 0033678985     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210000532     Document Type: Article

References (29)

1. Comparison of intracortical inhibition and facilitation in distal and proximal ann muscles in humans
2. A controlled trial of riluzole in amyotrophic lateral sclerosis
3. Riluzole - A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis
4. Effects of phenytoin on cortical excitability in humans
5. Magnetic transcranial stimulation at intensities below active motor threshold activates intracortical inhibitory circuits
6. Effects of riluzole on glutamatergic neurotransmission in the mammalian central nervous system, and other pharmacological effects
7. H reflexes and F waves: Physiology and clinical indications
8. Effects of diazepam, baclofen and thiopental on the silent period evoked by TMS in humans
9. Corticocortical inhibition in human motor cortex
10. Dose-ranging study of riluzole in amyotrophic lateral sclerosis
11. The glutamate antagonist riluzole suppresses intracortical facilitation
12. Effects of diphenylhydantoin on motor potentials evoked with magnetic stimulation
13. The electromyographic silent period produced by supramaximal electrical stimulation in normal man
14. Transcranial magnetic stimulation in partial epilepsy: Drug-induced changes of motor excitability
15. Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans
16. Influence of the N-methyl-D-aspartate antagonist memantine on human motor cortex excitability
17. Modulation of intracortical excitability for different muscles in the upper extremity: Paired magnetic stimulation study with focal versus non-focal coils
18. Riluzole does not have an acute effect on motor thresholds and the intracortical excitability in amyotrophic lateral sclerosis
19. Riluzole restores impaired intracortical inhibition in patients with ALS
20. Motor cortex inhibition in patients with ataxia
21. Pharmacological modulation of sodium channels by riluzole: An alternative to antiexcitotoxic actions
22. Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study
23. Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: Evidence from transcranial magnetic stimulation
24. The effect of lorazepam on the motor cortical excitability in man
25. Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study
26. Interaction between intracortical inhibition and facilitation in human motor cortex
27. Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs
28. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation
29. Dextromethorphan decreases the excitability of the human motor cortex