Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

Journal of Lipid Research

Volumn 43, Issue 1, 2002, Pages 45-50

  Xu, Guorong ^a,b   Pan, Lu Xing ^b   Erickson, Sandra K ^c   Forman, Barry M ^d   Shneider, Benjamin L ^e   Ananthanarayanan, M ^e   Li, Xiaogui ^b   Shefer, Sarah ^b   Balasubramanian, N ^e   Lin, Ma ^e   Asaoka, Hitoshi ^b   Lear, Steven R ^c   Nguyen, Lien B ^b   Dussault, Isabelle ^d   Suchy, Frederick J ^e   Tint, G Stephen ^a,b   Salen, Gerald ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bile salt export pump; Biosynthesis; Farnesoid X receptor; Ileal bile acid binding protein; Orphan nuclear receptor

Indexed keywords

BILE ACID; BILE ACID BINDING PROTEIN; BILE SALT EXPORT PUMP; BINDING PROTEIN; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; MESSENGER RNA; OXYGENASE; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; STEROL 12ALPHA HYDROXYLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; ENZYME INDUCTION; FAMILIAL HYPERLIPEMIA; ILEUM; IN VIVO STUDY; LIPID TRANSPORT; LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR DOWN REGULATION; TISSUE LEVEL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CARRIER PROTEINS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; DRAINAGE; HYDROXYSTEROID DEHYDROGENASES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RABBITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STEROID 12-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SYMPORTERS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0036165892     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Identification of a nuclear receptor that is activated by farnesol metabolite
2. Identification of a nuclear receptor for bile acids
3. Bile acids: Natural ligands for an orphan nuclear receptor
4. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
5. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene
6. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
7. Mechanisms and regulation of bile secretion
8. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
9. Molecular cloning and functional analysis of the promoter for bile salt export pump (BSEP) from human and mouse genes: Evidence for transactivation of the human promoter by farnesoid-X-receptor/retinoid-X-receptor (FXR/RXR)
10. Molecular cloning and characterization of the murine bile salt export pump
11. Characterization of cloned Na-bile acid transporter using peptide and fusion protein antibodies
12. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
13. Bile acid-mediated feedback inhibition of the NTCP gene promoter occurs via a novel mechanism involving bile acid receptor (FXR) activation of a transcriptional repressor
14. Ileal bile acid transport regulates bile acid pool, synthesis and plasma cholesterol levels differently in cholesterol-fed rats and rabbits
15. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
16. Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis
17. Glycocholic acid and glycodeoxycholic acid but not glycoursocholic acid inhibit bile acid synthesis in the rabbit
18. Neither intestinal sequestration of bile acids nor common bile duct ligation modulates the expression and function of the rat ileal bile acid transporter
19. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
20. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Purification of biologically active globin mRNA by chromatography on oligothymidylic acid-cellulose
22. Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by dietary cholesterol is not due to altered mRNA levels
23. Methods of assay
24. Protein measurement with the Folin phenol reagent
25. Regulation of bile acid synthesis by deoxycholic acid in the rat: Different effects on cholesterol 7α-hydroxylase and sterol 27-hydroxylase
26. Unexpected inhibition of cholesterol 7α-hydroxylase by cholesterol in New Zealand White and Watanabe heritable hyperlipidemic rabbits