Hypermethylation of the estrogen receptor alpha gene is not related to lack of receptor protein in human breast cancer

Breast Cancer

Volumn 6, Issue 2, 1999, Pages 79-86

  Hori, Masao ^a   Iwasaki, Mariko ^a   Yoshimi, Fuyo ^a   Asato, Yuji ^a   Itabashi, Masayuki ^a  

^a IBARAKI PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

Competitive polymerase chain reaction; DNA methylation; Estrogen receptor alpha gene; Transcriptional activity

Indexed keywords

EID: 0001790037     PISSN: 13406868     EISSN: 18804233     Source Type: Journal    
DOI: 10.1007/BF02966912     Document Type: Article

References (23)

1. Nomura Y Miura S, Koyama H, et al: Relative effect of Steroid hormone receptors on the prognosis of patients with operable breast cancer; A univariate and multivariate analysis of 3089 Japanese patients with breast cancer from the study group for the Japanese breast cancer society on hormone receptors and prognosis in breast cancer. Cancer 69:153-164, 1992.
2. Hori M, Katano M, Asato Y, et al: Frequencies of estrogen receptor mRNAs splice variants in various human mammary tissues. Breast Cancer 5:359-365, 1998.
3. Karnik PS, Kulkarni S, Liu X-P, et al: Estrogen receptor mutations in tamoxifen-resistant breast cancer. Cancer Res 54:349-353, 1994. (Pubitemid 24053165)
4. Li E, Beard C, Jaenisch R: Role for DNA methylation in genomic imprinting. Nature (Lond) 366:362-365, 1993. (Pubitemid 23349366)
5. Piva R, Bianchi N, Aguiari GL, et al: Sequencing of an RNA transcript of the human estrogen receptor gene; Evidence for a new transcriptional event. J Steroid Biochem Mol Biol 46:531-538, 1993. (Pubitemid 23346135)
6. Johnston SRD, Saccani-Jotti G, Smith IE, et al: Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Cancer Res 55:3331-3338, 1995.
7. Sambrook J, Fritsch EF, Maniatis T: Analysis and cloning of eukaryotic genomic DNA. In: Molecular Cloning; A Laboratory Manual, 2nd ed, Cold Spring Habor Laboratory, New York, pp 914-923, 1989.
8. Green S, Walter P, Kumar V, et al: Human oestrogen receptor cDNA; Sequence expression and homology to v-erb-A. Nature 320:134-139, 1986. (Pubitemid 16105150)
9. Keaveney M, Klug J, Dawson MT, et al: Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene. J Mol Endocrinol 6:111-115, 1991.
10. Brooks SC, Locke ER, Soule HD: Estrogen receptor in a human cell lines (MCF-7) from breast carcinoma. J Biol Chem 248:6251-6253, 1973.
11. Keydar I, Chen L, Karby S, et al: Establishment and characterization of a cell line of human breast cancer origin. Eur J Cancer 15:659-670, 1979. (Pubitemid 9198534)
12. Nishida M, Kasahara K, Oki A, et al: Establishment of eighteen clones of Ishikawa cells. Hum Cell 9:109-116, 1996.
13. Lapidus RG, Ferguson AT, Ottaviano YL, et al: Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors. Clin Cancer Res 2:805-810, 1996.
14. Lapidus RG, Nass SJ, Butash KA, et al: Mapping of ER gene CpG island methylation by methylationspecific polymerase chain reaction. Cancer Res 58:2515-2519, 1998. (Pubitemid 28275417)
15. Hayashi S, Imai K, Suga K, et al: Two promoters in expression of estrogen receptor messenger RNA in human breast cancer. Carcinogenesis 18:459-464, 1997. (Pubitemid 28132480)
16. Fuqua SAW: Estrogen receptor mutagenesis and hormone resistance. Cancer 74:1026-1029, 1994. (Pubitemid 24231998)
17. Fuqua SAW, Fitzgerald SD, Alfred C, et al: Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res 52:483-486, 1992.
18. Ohlsson H, Lykkesfeldt AE, Madsen MW, et al: The estrogen receptor variant lacking exon 5 has dominant negative activity in the human breast epithelial cell line HMT-3522S1. Cancer Res 58:4264-4268, 1998. (Pubitemid 28450022)
19. Kass SU, Pruss D, Wolffe AP, et al: How does DNA methylation repress transcription? Trends Genet 13:444-449, 1997. (Pubitemid 27479903)
20. Watts CKW, Handel ML, King RJB, et al: Oestrogen receptor gene structure and function in breast cancer. J Steroid Biochem Mol Biol 41:529-536, 1992.
21. Kuiper GGJM, Enmark E, Pelto-Huikko M, et al: Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930, 1996. (Pubitemid 26190778)
22. Cavailles V, Dauvois S, Danielian PS, et al: Interaction of proteins with transcriptionally active estrogen receptors. Proc Natl Acad Sci USA 91:10009-10013, 1994. (Pubitemid 24311938)
23. Kamei Y, Xu L, Heinzel T, et al: A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414, 1996. (Pubitemid 26160711)