Long-acting fentanyl analogues: Synthesis and pharmacology of N-(1-Phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 3, 2002, Pages 817-827

  Jagerovic, Nadine ^a   Cano, Carolina ^a   Elguero, José ^a   Goya, Pilar ^a   Callado, Luis F ^b   Javier Meana, J ^b   Girón, Rocío ^c   Abalo, Raquel ^c   Ruiz, David ^c   Goicoechea, Carlos ^c   Isabel Martin M ^c  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 [(1 OXOPROPYL)(1 PHENYLPYRAZOL 3 YL)AMINO] N PIPERIDINEPROPANOIC ACID METHYL ESTER; ANALGESIC AGENT; BENZENE DERIVATIVE; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; FENTANYL DERIVATIVE; MORPHINE; MU OPIATE RECEPTOR AGONIST; N (1 PHENYLPYRAZOL 3 YL) N (1 BENZYL 4 PIPERIDYL)PROPANAMIDE; N (1 PHENYLPYRAZOL 3 YL) N [1 (2 PHENETHYL) 4 PIPERIDYL)]PROPANAMIDE; N (1 PHENYLPYRAZOL 5 YL) N (1 BENZYL 4 PIPERIDYL)PROPANAMIDE; N (1 PHENYLPYRAZOL 5 YL) N [1 (2 PHENETHYL) 4 PIPERIDYL)PROPANAMIDE; N [1 (4 FLUOROPHENYL)PYRAZOL 3 YL] N (1 BENZYL 4 PIPERIDYL)PROPANAMIDE; N [1 (4 FLUOROPHENYL)PYRAZOL 3 YL] N [1 (2 PHENETHYL) 4 PIPERIDYL)]PROPANAMIDE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; PROPIONAMIDE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; AMIDE; DRUG DERIVATIVE; FENTANYL; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG BINDING; DRUG EFFECT; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; EVOKED MUSCLE RESPONSE; GUINEA PIG; HOT PLATE TEST; HUMAN; HUMAN CELL; ILEUM; MALE; MOUSE; MUSCLE CONTRACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; RABBIT; VAS DEFERENS; WRITHING TEST; ANIMAL; BINDING COMPETITION; BRAIN; CHEMISTRY; DRUG POTENTIATION; PAIN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME;

CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

AMIDES; ANALGESICS, OPIOID; ANIMALS; BINDING, COMPETITIVE; BRAIN; FENTANYL; GUINEA PIGS; HUMANS; MALE; MICE; MUSCLE CONTRACTION; PAIN; PYRAZOLES; RABBITS; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; VAS DEFERENS;

EID: 0036157899     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00345-5     Document Type: Article

References (45)