Structural modifications of the N-terminal tetrapeptide segment of [D- Ala2]Deltorphin I: Effects on opioid receptor affinities and activities in vitro and on antinociceptive potency

Peptides

Volumn 18, Issue 10, 1997, Pages 1615-1621

  Schmidt, Ralf ^b   Menard, Daniel ^b   Mrestani Klaus, Carmen ^c   Chung, Nga N ^a   Lemieux, Carole ^a   Schiller, Peter W ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b Astra Research Centre Montreal   (Canada)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

opioid agonists; Deltorphin analogs; Opioid analgesics

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN; DELTORPHIN I [2 DEXTRO ALANINE]; DELTORPHIN I DERIVATIVE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST; VAS DEFERENS;

ANALGESICS, OPIOID; ANIMALS; BRAIN; ELECTROPHYSIOLOGY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MUSCLE CONTRACTION; OLIGOPEPTIDES; PAIN MEASUREMENT; PROTEIN BINDING; RATS; RECEPTORS, OPIOID, DELTA; VAS DEFERENS;

EID: 0031425254     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00235-0     Document Type: Article

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