Cloning of the cat TSH receptor and evidence against an autoimmune etiology of feline hyperthyroidism

Endocrinology

Volumn 143, Issue 2, 2002, Pages 395-402

  Nguyen, Lynda Q ^a   Arseven, Onur Karamanoglu ^a   Gerber, Hans ^b   Stein, Barbara S ^c   Jameson, J Larry ^a   Kopp, Peter ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c Chicago Cat Clinic   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; IMMUNOGLOBULIN G; INOSITOL PHOSPHATE; LUCIFERASE; THYROTROPIN; THYROTROPIN RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CAT; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; GRAVES DISEASE; HYPERTHYROIDISM; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID FOLLICLE;

EID: 0036155922     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.2.8622     Document Type: Article

References (49)

1. Etiopathology of feline toxic nodular goiter
2. Hyperthyroidism in the cat: Ten cases
3. Toxic nodular goiter in the cat
4. Feline hyperthyroidism: Pretreatment and clinical evaluation of 131 cases
5. Feline hyperthyroidism
6. Epidemiology of thyroid diseases of dogs and cats
7. Autonomy of growth and of iodine metabolism in hyperthyroid feline goiters transplanted onto nude mice
8. Autonomous growth and function of cultured thyroid follicles from cats with spontaneous hyperthyroidism
9. The thyrotropin (TSH) receptor: Interaction with TSH and autoantibodies
10. Autoantibodies in feline hyperthyroidism
11. Thyroid growth immunoglobulins in feline hyperthyroidism
12. Pathogenesis of heterogeneity in human multinodular goiter
13. Hypo- and hyperthyroidism caused by mutations in the TSH receptor
14. The TSH receptor and its role in thyroid disease
15. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
16. Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism
17. Congenital hyperthyroidism caused by a germline mutation in the thyrotropin-receptor gene
18. Mutational analysis of the thyrotropin receptor gene in sporadic and familial feline thyrotoxicosis
19. Panning transfected cells for electrophysiological studies
20. The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding
21. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281→isoleucine) in the extracellular domain of the thyrotropin receptor
22. Studies on the mechanism of desensitization of the cyclic AMP response to TSH stimulation in a cloned rat thyroid cell line
23. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
24. Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene
25. Autoantibodies to the thyrotropin receptor
26. The thyrotropin receptor and the regulation of thyrocyte function and growth
27. The thyrotropin receptor and the regulation of thyrocyte function and growth: Update 1994
28. Resistance to TSH
29. Species specific action of Graves' serum on xenotransplanted human thyroid tissue
30. Direct comparison of the stimulatory effect of Graves's serum on thyroid tissue of 5 different species - A xenotransplantation study in nude mice
31. Effect of human stimulating autoantibodies on the radioiodine uptake of the mouse thyroid gland
32. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: Evidence for binding of autoantibodies
33. Molecular cloning of the thyrotropin receptor
34. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
35. Cloning, sequencing and expression of human TSH receptor
36. Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: Expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies
37. Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse
38. Bovine thyrotropin receptor cDNA is characterized by full-length and truncated transcripts
39. Cloning and expression of a brain-derived TSH receptor
40. A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling
41. q/11
42. The human thyrotropin receptor activates G-protein Gs and Gq11
43. Two-subunit structure of the human thyrotropin receptor
44. Evidence that the thyrotropin receptor ectodomain contains not one, but two cleavage sites
45. Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion
46. Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain
47. Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion
48. On the functional importance of thyrotropin receptor intramolecular cleavage
49. Evidence that cleavage of the thyrotropin receptor involves a "molecular ruler" mechanism: Deletion of amino acid residues 305-320 causes a spatial shift in cleavage site 1 independent of amino acid motif