Ets-1 flips for new partner Pax-5

Structure

Volumn 10, Issue 1, 2002, Pages 11-14

  Pufall, Miles A ^a   Graves, Barbara J ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN TARGETING; SHORT SURVEY; TRANSCRIPTION REGULATION;

EID: 0036151215     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00701-8     Document Type: Review

References (17)

1. Specificity within the ets family of transcription factors
2. The ETS-domain transcription factor family
3. Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif
4. A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex
5. The structure of GABPalpha/beta: An ETS domain-ankyrin repeat heterodimer bound to DNA
6. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: Insights into DNA sequence discrimination by Ets proteins
7. Structure of the Elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA
8. DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition
9. Structural studies of Ets-1/Pax5 complex formation on DNA
10. Inhibitory module of Ets-1 allosterically regulates DNA binding through a dipole-facilitated phosphate contact
11. Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter
12. The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex
13. The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes
14. Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly
15. Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix
16. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains
17. Autoinhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2