Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine

Thrombosis and Haemostasis

Volumn 87, Issue 1, 2002, Pages 122-128

  Wang, Junru ^a   Albertson, Christopher M ^a   Zheng, Huaien ^a   Fink, Louis M ^a   Herbert, Jean Marc ^a   Hauer Jensen, Martin ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Clopidogrel; Experimental; Intestine; Platelet aggregation; Radiation injuries; Radiation therapy

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; COLLAGEN; COLLAGEN TYPE 3; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ABDOMINAL RADIOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; ENDOTHELIUM INJURY; HISTOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MORPHOMETRICS; MUCOSA; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; RADIATION; RADIATION ENTEROPATHY; RADIATION INJURY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT COURSE THERAPY; SMALL INTESTINE; SMOOTH MUSCLE FIBER; STEADY STATE; STOMACH PROTECTION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0036149561     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1612954     Document Type: Article

References (46)

1. Radiation-induced apoptosis in microvascular endothelial cells
2. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
3. Vascular permeability and late radiation fibrosis in mouse lung
4. Effects of irradiation on endothelial cell-polymorphonuclear leukocyte interactions
5. E-selectin gene induction by ionizing radiation is independent of cytokine induction
6. On radiation-decreased fibrinolytic activity of vessel walls
7. The effect of ionizing radiation on endothelial tissue factor activity and its cellular localization
8. Ionizing radiation increases transcription of the von Willebrand factor gene in endothelial cells
9. Thrombomodulin as a marker of radiation-induced endothelial cell injury
10. Ionizing radiation enhances platelet adhesion to the extracellular matrix of human endothelial cells by an increase in the release of von Willebrand factor
11. Radiation-induced glomerular thrombus formation and nephropathy are not prevented by the ADP receptor antagonist clopidogrel
12. Synthesis of transforming growth factor-b1 by megacaryocytes and its localization to megacaryocyte and platelet α-granules
13. Recombinant soluble transforming growth factor-β type II receptor ameliorates radiation enteropathy in the mouse
14. ADP receptor on platelets
15. Effects of accelerated fractionation on radiation injury of the small intestine: A new rat model
16. Radiation injury in surgical pathology. Part II. Alimentary tract
17. Tolerance of rat small intestine to localized single dose and fractioned irradiation
18. Significance of overall treatment time for the development of radiation-induced intestinal complications. An experimental study in the rat
19. Late change following single dose roentgen irradiation of rat small intestine
20. Estimation of surface area from vertical sections
21. Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy
22. Association of transforming growth factor β (TGF-β) immunoreactivity with specific histopathologic lesions in subacute and chronic experimental radiation enteropathy
23. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections
24. Objective measurement of the different collagen types in the corpus cavernosum of potent and impotent men: An immunohistochemical staining with computerized-image analysis
25. Influence of short-term octreotide administration on chronic tissue injury, transforming growth factor β (TGF-β) overexpression, and collagen accumulation in irradiated rat intestine
26. Cellular sources of transforming growth factor β (TGF-β) isoforms in early and chronic radiation enteropathy
27. Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation
28. Zur Histologie der Röntgenulcera
29. The unique physiology of endothelial cells and its implication in radiobiology
30. Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta
31. Radiation-induced von Willebrand factor release
32. Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?
33. Prevention of ionizing radiation-induced liver microcirculation changes by the use of flow improvers
34. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate
35. Amelioration of radiation nephropathy by acetylsalicylic acid
36. Unwanted side-effects in using mesalazine (5-aminosalicylic acid) during radiotherapy
37. A randomized trial to assess the efficacy of 5-aminosalicylic acid for the prevention of radiation enteritis
38. The antiplatelet effects of ticlopidine and clopidogrel
39. Identification of the platelet ADP receptor targeted by antithrombotic drugs
40. Antiplatelet therapy
41. Therapeutic inhibition of platelet function in stroke
42. Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates
43. Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: Enhanced inhibitory effects of combination therapy
44. P2Y(12), a new platelet ADP receptor, target of clopidogrel
45. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
46. Thrombospondin causes activation of latent transforming growth factorβ secreted by endothelial cells by a novel mechanism