Epstein-Barr virus-encoded protein kinase BGLF-4 mediates hyperphosphorylation of cellular elongation factor 1δ (EF-1δ): EF-1δ is universally modified by conserved protein kinases of herpesviruses in mammalian cells

Journal of General Virology

Volumn 82, Issue 6, 2001, Pages 1457-1463

  Kato, K ^a   Kawaguchi, Y ^a   Tanaka, M ^a   Igarashi, M ^a   Yokoyama, A ^a   Matsuda, G ^a   Kanamori, M ^a   Nakajima, K ^a   Nishimura, Y ^a   Shimojima, M ^a   Phung, H T T ^a   Takahashi, E ^a   Hirai, K ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BGLF 4 PROTEIN; ELONGATION FACTOR 1; ELONGATION FACTOR 1DELTA; HYBRID PROTEIN; PHOSPHATASE; PHOSPHORUS 32; PROTEIN KINASE; UL 13 PROTEIN; UL 97 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPSTEIN BARR VIRUS; GENE EXPRESSION; GENETIC CODE; GENETIC CONSERVATION; GENETIC TRANSFECTION; HERPES VIRUS; HUMAN CYTOMEGALOVIRUS; ISOTOPE LABELING; MAMMAL CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; RNA TRANSLATION; VIRUS INFECTION;

EID: 17144468445     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-6-1457     Document Type: Article

References (34)

1. Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir
2. Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase
3. A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro
4. RNA polymerase of vesicular stomatitis virus specifically associates with translation elongation factor-1 alphabetagamma for its activity
5. Protein serine/threonine kinases
6. Functional and genetic analysis of the role of Vmw 110 in herpes simplex virus replication
7. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonine
8. The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22
9. Heterogeneity of feline herpesvirus type 1 strains
10. Interaction of herpesvirus simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery
11. Herpesvirus simplex virus 1α regulatory protein ICP0 interacts with and stabilized the cell cycle regulator cyclin D3
12. Eukaryotic elongation factor 1δ is hyperphosphorylated by the protein kinase encoded by the UL13 gene of herpes simplex virus 1
13. Cellular elongation factor 1δ is modified in cells infected with representative alpha-, beta-, or gammaherpesvirus
14. Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: Implication of cytoplasmic function of EBNA-LP
15. Virus-host cell interactions
16. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir
17. Mechanism and regulation of eukaryotic protein synthesis
18. Insect viruses
19. The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse
20. Molecular cloning of a new guanine-nucleotide exchange protein
21. Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF47-associated protein kinase
22. Partial substitution of the functions of the herpes simplex virus 1 UL13 gene by the human cytomegalovirus UL97 gene
23. UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: Glycoproteins E and I
24. The UL13 protein kinase and the infected cell type are determinants of post-translational modification of ICP0
25. A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency
26. The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein α22
27. Processing of the herpes simplex virus regulatory protein α22 mediated by the UL13 protein kinase determines the accumulation of a subset of α and γ mRNAs and proteins in infected cells
28. Eukaryotic protein elongation factors
29. The replication of the herpes simplex viruses
30. Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, Varicella-Zoster virus, and Epstein-Barr virus
31. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
32. SR alpha promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
33. Elongation factor EF-1β of artemia: Localization of functional sites and homology to elongation factor 1δ
34. Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation