Finding genes in the C2C12 osteogenic pathway by k-nearest-neighbor classification of expression data

Genome Research

Volumn 12, Issue 1, 2002, Pages 165-176

  Theilhaber, Joachim ^a   Connolly, Timothy ^a   Roman Roman, Sergio ^b   Bushnell, Steven ^a   Jackson, Amanda ^c   Call, Kathy ^a   Garcia, Teresa ^b   Baron, Roland ^b  

^a Cambridge Genomics Center   (United States)

^b SANOFI   (France)

^c CURAGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; BIOASSAY; BONE DEVELOPMENT; CALVARIA; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DNA MICROARRAY; FILTER; GENE AND NUCLEIC ACID PARAMETERS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC MODEL; GENETIC PROCEDURES; GENETIC SELECTION; HISTOGENESIS; IN VIVO STUDY; MOUSE; MUSCLE DEVELOPMENT; NOISE REDUCTION; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; VALIDATION PROCESS;

ANIMALS; BONE AND BONES; CELL LINE; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENETIC MARKERS; MICE; MUSCLE, SKELETAL; OSTEOGENESIS; SIGNAL TRANSDUCTION;

ANIMALIA; EUKARYOTA;

EID: 0036141951     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.182601     Document Type: Article

References (50)

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
2. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
3. Clustering expression patterns
4. Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones
5. Cytoplasmic activation of human nuclear genes in stable heterocaryons
6. Knowledge-based analysis of microarray gene expression data by using support vector machines
7. Analysis of gene expression microarrays for phenotype classification
8. cDNA fingerprinting of osteoprogenitor cells to isolate differentiation stage-specific genes
9. Transforming growth factor-β gene family members and bone
10. Statistical Tests
11. Selenoproteins are expressed in fetal human osteoblast-like cells
12. Nonparametric Techniques
13. Cluster analysis and display of genome-wide expression patterns
14. Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation
15. Nonparametric Classification and Error Estimation
16. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
17. Enhancement of vonnexin 43 rxpression increases proliferation and differentiation of an osteoblast-like vell line
18. Differentiation of muscle, fat, cartilage and bone from progenitor cells present in a bone-derived clonal cell population; effect of dexamethasone
19. Trans-differentiation of myoblasts to adipoblasts: Triggering effects of fatty acids and thiazolidinediones
20. Bone morphogenetic proteins in human bone regeneration
21. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
22. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β
23. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
24. The genetic transformation of bone biology
25. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
26. Non-parametric Statistical Tests
27. Cystatin C, an inhibitor of bone resorption produced by osteoblasts
28. Expression monitoring by hybridization to high-density oligonucleotide arrays
29. Prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme
30. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome
31. Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro
32. Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues
33. Gene expression in osteoblastic cells
34. Systematic variation in gene expression patterns in human cancer cell lines
35. Correlation and Concordance
36. Prostaglandin E receptor subtypes in mouse osteoblastic cell line
37. Osteoblast-specific factor 2: Cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I
38. Interpreting patterns of gene expression with self-organizing maps: Methods and applications to homeopoietic differentiation
39. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
40. Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells
41. Bayesian estimation of fold-changes in the analysis of gene expression: The PFOLD algorithm
42. The stem cell of the osteoblast
43. Significance analysis of microarrays applied to the ionizing radiation response
44. Large-scale temporal gene expression mapping of central nervous system development
45. A comparison of the expression pattern of five genes of the family of small leucine-rich proteoglycans during mouse development
46. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
47. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
48. Clonal osteogenic cell lines express myogenic and adipogenic developmental potential