Jerky, a protein deficient in a mouse epilepsy model, is associate with translationally inactive mRNA in neurons

Journal of Neuroscience

Volumn 22, Issue 1, 2002, Pages 176-182

  Liu, Wencheng ^a   Seto, Jeremy ^b   Donovan, Gerald ^c   Toth, Miklos ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c A Subsidiary of Lantheus Holdings   (United States)

Author keywords

Animal model; Epilepsy; Jerky; MRNA; Neuron; RNA binding protein; RNA protein interaction; Seizure; Translation

Indexed keywords

RIBONUCLEOPROTEIN; RNA BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EPILEPSY; GENE INACTIVATION; HIPPOCAMPUS; MESSENGER RNA SYNTHESIS; MOUSE; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING; TRANSLATION REGULATION; TRANSPOSON;

EID: 0036140462     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-01-00176.2002     Document Type: Article

References (40)

1. Familial temporal lobe epilepsy: A new syndrome with adolescent/adult onset and a benign course
2. Familial temporal lobe epilepsy: A common disorder identified in twins
3. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: Correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients
4. γ-aminobutyric acid (A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development
5. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex
6. Familial temporal lobe epilepsy: A clinically heterogeneous syndrome
7. CENP-B: A major human centromere protein located beneath the kinetochore
8. Defective chromosome segregation, microtubule bundling, and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice
9. HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure
10. In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries
11. Sensitivity to jerky gene dosage underlies epileptic seizures mice
12. Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma
13. Molecular cloning of cDNA for CEN P-B, the major human centromere autoantigen
14. Etiology and pathogenesis of temporal lobe epilepsy
15. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
16. Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice
17. A new locus for autosomal dominant nocturnal frontal lobe epilepsy maps to chromosome 1
18. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
19. Nitrocellulose filter binding for determination of dissociation constants
20. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice
21. Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights
22. Autosomal dominant temporal lobe epilepsy in a Japanese family
23. Initial sequencing and analysis of the human genome
24. The cenpB gene is not essential in mice
25. Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome, the proteome
26. Specificity and determinants of Sam68 RNA binding: Implications for the biological function of K homology domain
27. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system
28. Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME
29. JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24
30. Centromere protein B assembles human centromeric alpha-satellite DNA at the 17-bp sequence, CEN P-B box
31. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy
32. HuR, a RNA stability factor, is expressed in malignant brain tumors, binds to adenine-, uridine-rich elements within the 3′ untranslated regions of cytokine, angiogenic factor mRNAs
33. Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons
34. Centromeric protein B null mice are viable with no apparent abnormalities
35. Dominant partial epilepsies: A clinical, electrophysiological and genetic study of 19 Eur families
36. Autosomal dominant lateral temporal epilepsy: Clinical and genetic study of a large Basque pedigree linked to chromosome 10q
37. Autosomal dominant nocturnal frontal lobe epilepsy in a Spanish family with a Ser252Phe mutation in the CHRNA4 gene
38. CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins
39. Epileptic seizures caused by inactivation of a novel gene, jerky, related to centromere binding protein-B in transgenic mice
40. A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity