A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: Effects on DNA replication and late gene expression

Journal of Virology

Volumn 74, Issue 21, 2000, Pages 10122-10131

  McNamee, E E ^a   Taylor, T J ^a   Knipe, D M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; SINGLE STRANDED DNA; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; DNA DETERMINATION; DNA REPLICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HERPES VIRUS; PHENOTYPE; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMAL; CELL LINE, TRANSFORMED; CELL NUCLEUS; CELL TRANSFORMATION, VIRAL; CERCOPITHECUS AETHIOPS; DNA REPLICATION; GENE EXPRESSION; HERPESVIRUS 1, HUMAN; MODELS, BIOLOGICAL; MUTATION; SUPPORT, U.S. GOV'T, P.H.S.; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0033771321     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.21.10122-10131.2000     Document Type: Article

References (41)

1. Identification of a novel nuclear site
2. ND10 protein PML is recruited to herpes simplex virus type prereplicative sites and replication compartments in the presence of viral DNA polymerase
3. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein
4. Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA
5. A method for identifying the viral genes required for herpesvirus DNA replication
6. A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription
7. Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides
8. Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein
9. Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures
10. Comparison of the intranuclear distributions of herpes simplex virus proteins involved in different viral functions
11. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
12. The disruption of ND10 during herpes simplex virus infection correlates with the Vmw1 10- and proteasome-dependent loss of several PML isoforms
13. HSV-1 IE protein VMW 110 causes redistribution of PML
14. Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein
15. Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression
16. Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes
17. Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression
18. Transcriptional control of herpes-virus gene expression: Gene functions required for positive and negative regulation
19. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition
20. Cell growth transformation by herpes simplex virus
21. Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4
22. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment
23. Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons
24. Association of herpes simplex virus regulatory, protein ICP22 with transcriptional complexes containing EA, ICP4, RNA polyrnerase II, and viral DNA requires posttranslational modification by the U(L)13 protein kinase
25. Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures
26. Herpes simplex virus type 1 prereplicative sites are a heterogeneous population: Only a subset are likely to be precursors to replication compartments
27. Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication
28. The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICPO
29. Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)
30. Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type 1
31. Herpes simplex virus gene expression in neurons: Viral DNA synthesis is a critical regulatory event in the branch point between the lyric and latent pathways
32. Nuclear sites of herpes simplex virus type 1 DNA replication and transcription colocalize at early times postinfection and are largely distinct from RNA processing factors
33. The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication
34. Intranuclear localization of herpessimplex virus immediate-early and delayed-early proteins: Evidence that ICP 4 is associated with progeny virus DNA
35. RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection
36. Herpes simplex viruses and their replication
37. n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses
38. Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4
39. Repression of host RNA polymerase II transcription by herpes simplex virus type 1
40. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites
41. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells