Reappearance of HIV multidrug-resistance in plasma and circulating lymphocytes after reintroduction of antiretroviral therapy

Journal of Clinical Virology

Volumn 24, Issue 1-2, 2002, Pages 93-98

  Albrecht, Dirk ^a,b   Zöllner, Bernhard ^c   Feucht, Heinz Hubert ^c   Lorenzen, Thore ^a   Laufs, Rainer ^c   Stoehr, Albrecht ^a   Plettenberg, Andreas ^a  

^a Institute for Interdisciplinary Infectiology and Immunology (IFI)   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Antiretroviral therapy; HIV archival variant; HIV drug resistance mutations; HIV sequence variability; Therapy interruption

Indexed keywords

ABACAVIR; AMPRENAVIR; DIDANOSINE; EFAVIRENZ; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; VIRUS DNA; ZALCITABINE; ZIDOVUDINE;

ADULT; ANALYTIC METHOD; ARTICLE; CASE REPORT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENCY; GENE SEQUENCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; MALE; MULTIDRUG RESISTANCE; PLASMA; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS LOAD; VIRUS MUTATION; VIRUS RESISTANCE;

ADULT; ANTI-HIV AGENTS; CHRONIC DISEASE; DNA, VIRAL; DRUG RESISTANCE, MULTIPLE, VIRAL; DRUG THERAPY, COMBINATION; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; LONGITUDINAL STUDIES; LYMPHOCYTES; MALE; MUTATION; TREATMENT REFUSAL; VIRAL LOAD;

EID: 0036137396     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(01)00231-1     Document Type: Article

References (13)

1. HIV-1 evolution under pressure of protease inhibitors: Climbing the stairs of viral fitness
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3. Rapid decline in detectability of HIV-1 drug-resistance mutations after stopping therapy
4. Confidence limits on phylogenies: An approach using the bootstrap
5. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
6. Mutations in retroviral genes associated with drug resistance
7. Changes in human immunodeficiency virus type 1 populations after treatment interruption in patients failing antiretroviral therapy
8. Quantification of integrated and total HIV-1 DNA after long-term highly active antiretroviral therapy in HIV-1-infected patients
9. Human immunodeficiency virus proviral DNA from peripheral blood and lymph nodes demonstrates concordant resistance mutations to zidovudine (codon 215) and didanosine (codon 74)
10. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
11. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
12. Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy
13. Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype