Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 339-341

  Li, Yanlong ^a   Eiseman, Julie L ^b,c   Sentz, Dorothy L ^b   Rogers, Faye A ^a   Pan, Su Shu ^b,c   Hu, Li Tai ^b   Egorin, Merrill J ^b,c   Callery, Patrick S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,12 DIAZIRIDINYL 4,9 DIAZADODECANE; CHLORMETHINE; CHLORMETHINE DERIVATIVE; DNA; MELPHALAN; NSC 667005; POLYAMINE; POLYAMINE DERIVATIVE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; MURINE LEUKEMIA; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; AZIRIDINES; CROSS-LINKING REAGENTS; DNA; ELECTROPHORESIS, AGAR GEL; FEMALE; LEUKEMIA L1210; MECHLORETHAMINE; MELPHALAN; MICE; MICE, INBRED STRAINS; SPERMINE; THIOTEPA;

EID: 0030028138     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9500885     Document Type: Article

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