D-Ala:D-Ala ligase gene flanking the vanC cluster: Evidence for presence of three ligase genes in vancomycin-resistant Enterococcus gallinarum BM4174

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 1, 2002, Pages 95-100

  Ambur O H ^a   Reynolds, P E ^a   Arias, C A ^a  

^a UNIVERSIDAD EL BOSQUE   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL ENZYME; BACTERIAL PROTEIN; DEXTRO ALANINE DEXTRO ALANINE LIGASE; DEXTRO ALANINE DEXTRO SERINE LIGASE; GENE PRODUCT; NUCLEOTIDE; PENTAPEPTIDE; PEPTIDOGLYCAN; PROTEIN DDL; PROTEIN DDL2; PROTEIN VANC; PROTEIN VANC 1; UNCLASSIFIED DRUG; VANCOMYCIN;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENETICS; BACTERIUM CULTURE; CONTROLLED STUDY; ELECTROPORATION; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS GALLINARUM; GENE EXPRESSION; GENE FUNCTION; GENETIC ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STOP CODON; THIN LAYER CHROMATOGRAPHY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; ENTEROCOCCUS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PEPTIDE SYNTHASES; SEQUENCE HOMOLOGY, AMINO ACID; VANCOMYCIN RESISTANCE;

EID: 0036136147     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.1.95-100.2002     Document Type: Article

References (41)

1. vanC cluster of vancomycin resistant Enterococcus gallinarum BM4174
2. Characterization and modelling of VanT, a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174
3. Contribution of Van Y D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors
4. Glycopeptide resistance in enterococci
5. Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci
6. Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococeus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum
7. XL1-Blue - A high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection
8. Roles of the two [ysy]-tRNA synthetases of Escherichia coli: Analysis of nucleotide sequences and mutant behavior
9. High efficiency introduction of plasmid DNA into glycine-treated Enterococcus faecalis by electroporation
10. Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance
11. Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: Interchangeability of the two anthranilate synthases and evolutionary implications
12. Evolution of structure and substrate specificity in D-alanine:D-alanine ligases and related enzymes
13. Vancomycin resistance: Structure of D-alanine:D-alanine ligase at 2.3 Å resolution
14. Vancomycin-dependent Enterococcus faecalis
15. VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis
16. Urinary tract infection with an Enterococcus faecalis isolate that requires vancomycin for growth
17. Biosynthetic alr alanine racemase from Salmonella typhimurium: DNA and protein sequence determination
18. The occurrence of two dehydroquinases in Neurospora crassa, one constitutive and one inducible
19. Bacteremia due to vancomycin-dependent Enterococcus faecium
20. Vancomycin resistance is associated with serine-containing peptidoglycan in Enterococcus gallinarum
21. Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases
22. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
23. Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci
24. Mutational analysis of active-site residues of the enterococcal D-Ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-Ala:D-Ala ligase and D-Ala-D-Ala carboxypeptidase VanY
25. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia colo and Synechocystis: Attributes of catalytic efficiency, stereoselectivity and regulation with implications for function
26. Genetic characterization of vanG, a novel vancomycin resistance locus in Enterococcus faecalis
27. Nucleotide sequences that signal the initiation of transcription and translation in Bacillus subtilis
28. Rapid extraction of bacterial genomic DNA with guanidinium thiocyanate
29. c encodes both D,D-dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174
30. Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174
31. Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine
32. The molecular basis of vancomycin resistance in clinically relevant enterococci: Crystal structure of D-alanyl-D-lactate ligase (VanA)
33. DNA sequencing with chain-terminating inhibitors
34. Active site mapping of Escherichia coli D-Ala:D-Ala ligase by structure-based mutagenesis
35. Vancomycin dependence in a VanA-producing Enterococcus avium strain with a nonsense mutation in the natural D-Ala:D-Ala ligase gene
36. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
37. Amino acid biosynthesis and its regulation
38. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants
39. Two alanine racemase genes in Salmonella typhimurium that differ in structure and function
40. Existence of two D-alanine:D-alanine ligases in Escherichia coli: Cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes