Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing

Molecular and Cellular Biology

Volumn 22, Issue 2, 2002, Pages 614-625

  Krawitz, D C ^a   Kama, T ^a   Kaufman, P D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN ASSEMBLY FACTOR I; CYCLINE; DNA; GENE PRODUCT; HISTONE H3; HISTONE H4; PROTEIN; PROTEIN ASF1; PROTEIN CAC1; PROTEIN CAC1P; PROTEIN CAC2P; PROTEIN CAC3; PROTEIN CAC3P; PROTEIN HIR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; GENE MUTATION; GENE SILENCING; GENETIC SCREENING; IN VITRO STUDY; MUTANT; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; TELOMERE;

ALLELES; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE SILENCING; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; PLASMIDS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN SUBUNITS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TELOMERE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036135016     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.2.614-625.2002     Document Type: Article

References (62)

1. A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair
2. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics
3. Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1
4. Chromatin assembly factor I contributes to the maintenance, but not the reestablishment, of silencing at the yeast silent mating loci
5. RLF2, a subunit of yeast chromatin assembly factor I, is required for telomeric chromatin function in vivo
6. Chromatin assembly coupled to DNA repair: A new role for chromatin assembly factor I
7. Role of Saccharomyces cerevisiae chromatin assembly factor I in repair of ultraviolet radiation damage in vivo
8. Gene silencing: Two faces of SIR2
9. Position effect at S. cerevisiae telomeres: Reversible repression of PolII transcription
10. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
11. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
12. Structure of the C-terminal region of p21 complexed with PCNA
13. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
14. Postreplicative chromatin assembly by Drosophila and human chromatin assembly factor I
15. His proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I
16. The p150 and p60 subunits of chromatin assembly factor I: A molecular link between newly synthesized histones and DNA replication
17. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cell lacking chromatin assembly factor I
18. FASCIATA genes for chromatin assembly factor-I in arabidopsis maintain the cellular organization of apical meristems
19. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast
20. Nucleosome assembly during complementary DNA strand synthesis in extracts from mammalian cells
21. Two new S-phase-specific genes from Saccharomyces cerevisiae
22. Genetic analysis of histone H4: Essential role of lysines subject to reversible acetylation
23. A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
24. The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres
25. A rapid method for localized mutagenesis of yeast genes
26. A human homologue of yeast anti-silencing factor has histone chaperone activity
27. Heterochromatin dynamics in mouse cells: Interaction between chromatin assembly factor 1 and HP1 proteins
28. The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition
29. Trans-acting regulatory mutations that alter transcription of Saccharomyces cerevisiae histone genes
30. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory (Hir) proteins
31. Dimerization of the largest subunit of chromatin assembly factor 1: Importance in vitro and during Xenopus early development
32. Assays for nucleosome positioning in yeast
33. Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the CDK inhibitor PHO81
34. Yeast histone deposition protein Asf1p requires Hit proteins and PCNA for heterochromatic silencing
35. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
36. The Sir2 protein family: A novel deacetylase for gene silencing and more
37. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
38. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
39. A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors
40. Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication
41. Stepwise assembly of chromatin during DNA replication in vitro
42. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle
43. Chromatin assembly during SV40 DNA replication in vitro
44. Yeast ASF1 protein is required for cell-cycle regulation of histone gene transcription
45. Duplication and maintenance of heterochromatin domains
46. A truncated form of the human CAF-1 p150 subunit impairs the maintenance of transcriptional gene silencing in mammalian cells
47. Elevated recombination rates in transcriptionally active DNA
48. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation
49. The RCAF complex mediates chromatin assembly during DNA replication and repair
50. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors
51. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase
52. Nucleosome assembly by a complex of CAF-I and acetylated histones H3/H4
53. PCNA binding through a conserved motif
54. The puzzle of PCNA's many partners
55. PCNA binding proteins in Drosophila melanogaster: The analysis of a conserved PCNA binding domain
56. Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae
57. A novel pena-binding motif identified by the panning of a random peptide display library
58. Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase delta
59. PCNA connects DNA replication to epigenetic inheritance in yeast
60. A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: Affinity, stoichiometry, and thermodynamics