Unifying themes in DNA replication: Reconciling single molecule kinetic studies with structural data on DNA polymerases

Journal of Biomolecular Structure and Dynamics

Volumn 19, Issue 4, 2002, Pages 571-584

  Goel, Anita ^a   Ellenberger, Tom ^b   Frank Kamenetskii, Maxim D ^c   Herschbach, Dudley ^d  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Boston University   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE;

ARTICLE; DNA REPLICATION; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; THERMODYNAMICS;

BINDING SITES; DNA; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; TEMPLATES, GENETIC; THERMODYNAMICS;

EID: 0036131333     PISSN: 07391102     EISSN: None     Source Type: Journal    
DOI: 10.1080/07391102.2002.10506764     Document Type: Article

References (26)

1. Single-molecule studies of the effect of template tension on T 7 DNA polymerase activity
2. Replication by a single DNA polymerase of a stretched single stranded DNA
3. Conformational coupling in DNA polymerase fidelity
4. DNA replication fidelity
5. DNA polymerases: Structural diversity and common mechanisms
6. An open and closed case for all polymerases
7. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
8. Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
9. Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: Structural basis for nucleotide incorporation
10. Tuning DNA "strings": Modulating the rate of DNA replication with mechanical tension
11. The mechanism of action of T7 DNA polymerase
12. Force-induced melting of the DNA double helix 1. Thermodynamic analysis
13. Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
14. Overstretching B-DNA: The elastic response of individual double-stranded and single stranded DNA molecules
15. In defence of the high energy phosphate bond
16. Force and velocity measured for single molecules of RNA polymerase
17. Aspects of protein reaction dynamics: Deviations from simple behavior
18. Resonant activation over a fluctuating barrier
19. Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication
20. Single-molecule study of transcriptional pausing and arrest by E.coli RNA polymerase
21. Molecular dynamics simulation of nucleic acids