Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice

Synapse

Volumn 44, Issue 2, 2002, Pages 94-105

  Turman Jr , Jack E ^a   Lee, Ophelia K ^b   Chandler, Scott H ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cocaine; Dopamine; Dopamine transporter; RTI 55

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; AMINE; COCAINE; DOPAMINE TRANSPORTER; HOMOCOCAINE; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; VIRUS T ANTIGEN;

AMINE TRANSPORT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN MEMBRANE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MALE; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SOUTHERN BLOTTING;

ALGORITHMS; ANIMALS; BINDING SITES; BIOGENIC AMINES; BRAIN; CAUDATE NUCLEUS; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MEMBRANES; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SYMPORTERS;

EID: 0036128564     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10060     Document Type: Article

References (15)

1. 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter
2. Secondary amine analogues of 3 beta-(4′-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters
3. Cocaine and 3 beta-(4′-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter
4. Resistance of dopamine transporter knock-out mice to methamphetamine neurotoxicity is not related to lack of core temperature elevation or marked depletion of brain dopamine
5. Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type
6. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
7. Oxygenated analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperaz ines (GBR12935 and GBR12909) as potential extended-action cocaine-abuse therapeutic agents
8. Distribution of neurons expressing immunoreactivity for the 5HT3 receptor subtype in the rat brain and spinal cord
9. Extracellular cocaine and dopamine concentrations are linearly related in rat striatum
10. 125I]RTI-55
11. 125I]RTI-55, in membranes prepared from whole rat brain minus caudate
12. 125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate
13. Neurochemical neutralization of methamphetamine with high affinity non-selective inhibitors of biogenic amine transporters: A pharmacological strategy for treating stimulant abuse
14. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
15. Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909)