Markers of central nervous system glia and neurons in vivo during normal and pathological conditions

Current Topics in Microbiology and Immunology

Volumn 265, Issue , 2002, Pages 119-140

  Redwine, J M ^a,c   Evans, C F ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Digital Genes Technologies Inc   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER;

ASTROCYTE; BRAIN DISEASE; BRAIN NERVE CELL; CELL FUNCTION; CELL POPULATION; CELL STRUCTURE; GENE EXPRESSION; GLIA CELL; HUMAN; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MICROGLIA; OLIGODENDROGLIA; PATHOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; STEM CELL; VIRUS INFECTION;

ANIMALS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM; HUMANS; NEUROGLIA; NEURONS;

EID: 0036126794     PISSN: 0070217X     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-3-662-09525-6_6     Document Type: Review

References (155)

1. Demonstration of poly-N-acetyl lactosamine residues in amoeboid and ramified microglial cells in rat brain by tomato lectin binding
2. Macrophage histology in paraffin-embedded multiple sclerosis plaques is demonstrated by the monoclonal pan-macrophage marker HAM-56: Correlation with chronicity of the lesion
3. An ultrastructural study of the phagocytic activity of astrocytes in adult rat brain
4. Macrophages/microglial cells in human central nervous system during development: An immunohistochemical study
5. F4/80, a monoclonal antibody directed specifically against the mouse macrophage
6. Molecular pathogenesis of multiple sclerosis
7. Adhesion molecule expression and phenotype of glial cells in the olfactory tract
8. Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: A light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique
9. Anti mac-1 selectively inhibits the mouse and human type three complement receptor
10. Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain
11. Astrocytes as active participants of glutamatergic function and regulators of its homeostasis
12. Expression of the APC tumor suppressor protein in oligodendroglia
13. Localization of glial fibrillary acidic protein in astrocytes by immunofluorescence
14. Biochemical and immunohistochemical studies with specific polyclonal antibodies directed against bovine myelin/oligodendrocyte glycoprotein
15. The perinodal astrocyte
16. Mature microglia resemble immature antigen-presenting cells
17. Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells
18. Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation
19. Radial glia phenotype: Origin, regulation, and transdifferentiation
20. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
21. The distribution of transferrin immunoreactivity in the rat central nervous system
22. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity
23. NG2-expressing cells in the central nervous system: Are they oligodendroglial progenitors?
24. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
25. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies EDI, ED2 and ED3
26. Generation and characterization of mouse monoclonal antibodies to the myelin-associated glycoprotein (MAG)
27. Astrocytes are the primary source of tissue factor in the murine central nervous system; a role for astrocytes in cerebral hemostasis
28. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
29. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
30. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease
31. Microglia and astroglia have a common progenitor cell
32. Proliferating bipotential glial progenitor cells in adult rat optic nerve
33. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared
34. Neuron-specific enolase: Complete structure of rat mRNA, multiple transcriptional start sites, and evidence suggesting post-transcriptional control
35. Tumor necrosis factor alpha expression in the spinal cord of human T-cell lymphotrophic virus type I associated mylopathy/tropical spastic paraparesis patients
36. P2 receptor-mediated proliferative effects on astrocytes in vivo
37. In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, Rip
38. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein
39. Cloning and cDNA sequence analysis of myelin/oligodendrocyte glycoprotein: A novel member of the immunoglobulin gene superfamily
40. Microglia: Intrinsic immunoeffector cell of the brain
41. Plasticity in the adult human oligodendrocyte lineage
42. A reappraisal of ganglioside GD3 expression in the CNS
43. Distinct neuronal subset reveals perikaryal immunostaining for synaptophysin (protein p38) in the striatum of rats
44. Identity of ED2-positive perivascular cells in rat brain
45. Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane
46. Production and characterization of monoclonal antibodies against the "brain-specific" proteins 14-3-2 and S-100
47. PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O 2 A) cell lineage
48. Fate of adult neural precursors grafted to adult cortex monitored with a Y-chromosome marker
49. RCA-I lectin histochemistry after trypsinisation enables the identification of microglial cells in thin paraffin sections of the mouse brain
50. Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
51. Perivascular microglial cells of the CNS are bone marrow derived and present antigen in vivo
52. Bone marrow-derived elements in the central nervous system: An immunohistochemical and ultrastructnral survey of rat chimeras
53. Mac-1 antigen: Quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen
54. Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein
55. Developmental expression of the myelin gene MOBP in the rat nervous system
56. Interactions between macrophages and legionella pneumophila
57. Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the central nervous system: Astrocytes fail to express major histocompatibility complex class I and II molecules
58. Primary demyelination in transgenic mice expressing interferon-gamma
59. Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain
60. Macrophage markers in diagnostic neuropathology
61. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
62. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
63. Microglia: The effector cell for reconstitution of the central nervous system following bone marrow transplantation for lysosomal and peroxisomal storage diseases
64. Interpreting MHC class I expression and class I/classII reciprocity in the CNS: Reconciling divergent findings
65. Turcot's syndrome: Evidence for linkage to the adenomatous polyposis coli(APC) locus
66. Adhesion molecule expression and regulation on cells of the central nervous system
67. Differentiation of cerebellar bipotential glial precursors into oligodendrocytes in primary culture: Developmental profile of surface antigens and mitotic activity
68. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
69. Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: Association with smooth protoplasmic astrocytes
70. The oligodendrocyte precursor cell in health and disease
71. Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen
72. Development and differentiation of glial precursor cells in the rat cerebellum
73. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain
74. Five mouse tubulin isotypes and their regulated expression during development
75. The origin and nature of ramified and amoeboid microglia: A historical review and current concepts
76. The topographical distribution of S-100 and GFA proteins in the adult rat brain: An immunohistochemical study using horseradish peroxidase-labelled antibodies
77. Divergent lineages for oligodendrocytes and astrocytes originating in the neonatal forebrain subventricular zone
78. Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cells: An ultrastructural analysis of clonally related cells
79. A specific histochemical marker (lectin ricinus communis agglutinin-1) for normal human microglia and application to routine histopathology
80. The existence and neurobiological significance of neuronal and glial forms of the glycolytic enzyme enolase
81. Neuronal, non-neuronal and hybrid forms of enolase in brain: Structural, immunological and functional comparisons
82. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
83. CDIIb (mac-I); a marker for CD8+ cytotoxic T cell activation and memory in virus infection
84. Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1
85. Immunocytochemical detection of the growth-associated protein B-50 by newly characterized monoclonal antibodies in human brain and muscle
86. Affinity purification of human tau proteins and the construction of a sensitive sandwich enzyme-linked immunosorbent assay for human tau detection
87. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination
88. Glial cell heterogeneity in the mammalian spinal cord
89. Reactive proliferation of astrocytes studied by immunohistochemistry for proliferating cell nuclear antigen
90. Oligodendrocyte reactions and cell proliferation markers in human demyelinating diseases
91. NeuN, a neuronal specific nuclear protein in vertebrates
92. Physiology of bergmann glial cells
93. Microglial conditioned medium promotes survival and development of cultured mesencephalic neurons from embryonic rat brain
94. NG2+ glial cells: A novel glial cell population in the adult brain
95. Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2 A progenitor cells in the developing rat brain
96. Normal and reactive NG2+ glial cells are distinct from resting and activated microglia
97. Cell reactions following acute brain injury: A review
98. Developmental expression of platelet-derived growth factor alpha receptor in neurons and glial cells of the mouse CNS
99. An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
100. Expression of a homologue of rat NG2 on human microglia
101. APC mutations occur early during colorectal tumorgenesis
102. PDGF receptors in the rat CNS: During late neurogenesis, PDGF alpha receptor appears to be restricted to glial cells of the oligodendrocyte lineage
103. A singularity of PDGF alpha receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage
104. Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties
105. In vivo proliferation of oligodendrocyte progenitors expressing PDGF-alpha receptor during early remyelination
106. In vivo expression of MHC molecules on oligodendrocytes and neurons during viral infection
107. Generation of a monoclonal antibody against the myelin protein CNP suitable for biochemical and for immunohistochemical investigations of CNP
108. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo
109. Development of macroglial cells in the rat cerebellum II. An in situ immunohistochemical study of oligodendroglial lineage from precursor to mature myelinating cell
110. Microglia progenitor cells: A subpopulation on cultures of mouse neopallial astroglia
111. S100 protein expression in subpopulations of neurons of rat brain
112. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3
113. Immune response gene products (la antigens) on glial and endothelial cells in virus-induced demyelination
114. Brain endolases as specific markers of neuronal and glial cells
115. Binding patterns of mistletoe lectins I, II and III to microglia and Alzheimer plaque glycoproteins in human brains
116. Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
117. An immunofluorescence microscopical study of the neurofilament triplet proteins, vimentin and glial fibrillary acidic protein within the adult rat brain
118. The localization of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in bovine cerebrum by immunofluorescence
119. Morphometric analysis of normal, mutant, and transgenic CNS: Correlation of myelin basic protein expression to myelinogenesis
120. Tissue fixation methods alter the immunohistochemical demonstrability of neurofilament proteins, synaptophysin, and glial fibrillary acidic protein in human cerebellum
121. The APC gene product in normal and tumor cells
122. Immunolocalization of proteolipid protein peptide 103-116 in myelin
123. Monoclonal antibodies (O1 and O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system
124. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
125. The NG2 antigen, a putative lineage marker: Immunofluorescent localization in primary cultures of rat brain
126. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan proteoglycan
127. Cell-surface molecules that characterize different stages in the development of cerebellar interneurons
128. The mouse macrophage- specific glycoprotein defined by monoclonal antibody F4/80: Characterization, biosynthesis and demonstration of a rat analogue
129. Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation
130. Myelin associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rats
131. Functional plasticity of microglia: A review
132. Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin
133. Lectin binding by resting and, reactive microglia
134. Development of polyclonal antibodies and evaluation of a sensitive radioimmunoassay for detection and measurement of synaptophysin
135. Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus
136. TOGA: An automated parsing technology for analyzing expression of nearly all genes
137. Identification of normal microglia population in human and rodent nervous tissue using lectin-histochemistry
138. A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal horn
139. The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes
140. Neuronal microtubule-associated proteins in the embryonic avian spinal cord
141. Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro
142. Increase in glial fibrillary acidic protein following neural trauma
143. A monoclonal antibody directed against the nurine macrophage surface molecule F4/80 modulates natural immune response to listeria monocytogenes
144. The influence of long-term potentiation on the spatial relationship between astrocyte processes and potentiated synapses in the dentate gyrus neuropil of rat brain
145. Metabolic trafficking between neurons and astrocytes: The glutamate/glutamine cycle revisited
146. Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: An immunodominant region which induces nonreciprocal CTL cross-reactivity
147. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles
148. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
149. Antisera specific for cell lines with mixed neuronal and glial properties
150. Antisera specific for cell lines with mixed neuronal and glial properties
151. Identification of an adult-specific glial progenitor cell
152. Distribution of a specific calcium-binding protein of the S100 protein family, S100A6 (calcyclin), in subpopulations of neurons and glial cells of the adult rat nervous system
153. Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo
154. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation