In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection

American Journal of Pathology

Volumn 159, Issue 4, 2001, Pages 1219-1224

  Redwine, J M ^a   Buchmeier, M J ^a   Evans, C F ^a  

^a Digital Gene Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEMYELINATION; ENDOTHELIUM; FEMALE; IMMUNOFLUORESCENCE; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; MURINE HEPATITIS CORONAVIRUS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

EID: 0034790728     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62507-2     Document Type: Article

References (40)

1. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis
2. Theiler's murine encephalomyelitis: A model of demyelination and persistence of virus
3. A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination
4. Interpreting MHC class I expression and class I/class II reciprocity in the CNS: Reconciling divergent findings
5. Site-specific alteration of murine hepatitis virus type-4 peplomer glycoprotein E2 results in reduced neurovirulence
6. The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system
7. Progressive multifocal leukoencephalopathy
8. Pathogenesis of mouse hepatitis virus-induced demyelination
9. Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity
10. Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody
11. Perforin-dependent neurologic injury in a viral model of multiple sclerosis
12. An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence
13. Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
14. Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system
15. Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes
16. Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-gamma and TNF-alpha
17. MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
18. Immune response gene products (la antigens) on glial and endothelial cells in virus-induced demyelination
19. Detailed in vivo analysis of interferon-gamma induced MHC expression in the CNS: Astrocytes fail to express MHC class I and II molecules
20. Neuronal cells are deficient in loading peptides onto MHC class I molecules
21. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo
22. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity
23. Functional requirement for class I MHC in CNS development and plasticity
24. Induction of MHC class I genes in neurons
25. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
26. MHC class I-restricted killing of neurons by virus-specific CD8 T lymphocytes is effected through the fas/fasL, but not the perforin pathway
27. Cell surface expression of H2 antigens on primary sensory neurons in response to acute but not latent herpes simplex virus infection in vivo
28. Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus
29. Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-gamma and tumor necrosis factor-alpha
30. Coronavirus induction of class I major histocompatibility complex expression in murine astrocytes is virus strain specific
31. Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides
32. Intercellular regulation of major histocompatibility complex class I expression in neural cells
33. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
34. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
35. Antigen presenting capacity of brain microvasculature in altered peptide ligand modulation of experimental allergic encephalomyelitis
36. Microglia: Intrinsic immunoeffector cell of the brain
37. Tissue and cellular distribution of an adhesion molecule in the carcinoembryonic antigen family that serves as a receptor for mouse hepatitis virus
38. Role of virus receptor-bearing endothelial cells of the blood-brain barrier in preventing the spread of mouse hepatitis virus-A59 into the central nervous system
39. Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM
40. The functional significance of epitope spreading and its regulation by co-stimulatory molecules