Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats

Carcinogenesis

Volumn 23, Issue 2, 2002, Pages 283-287

  Futakuchi, Mitsuru ^a   Hirose, Masao ^a,b   Imaida, Katsumi ^a   Takahashi, Satoru ^a   Ogawa, Kumiko ^a   Asamoto, Makoto ^a   Miki, Tokutaro ^c   Shirai, Tomoyuki ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c Nippon Hypox Laboratories Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 O HEXYL 2,3,5 TRIMETHYLHYDROQUINONE; 1,2 DIMETHYLHYDRAZINE; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CHEMOPROPHYLAXIS; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; DNA ADDUCT; DOSE RESPONSE; DUODENUM CARCINOMA; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; RAT; RAT STRAIN;

EID: 0036119631     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.2.283     Document Type: Article

References (36)

1. Heterocyclic amine mutagenicity/carcinogenicity: Influence of repair, metabolism and structure
2. Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice
3. Intake of fried meat and risk of cancer: A follow-up study in Finland
4. Meat, cooking methods and colorectal cancer: A case-referent study in Stockholm
5. Mutagenicity of human urine caused by ingestion of fried ground beef
6. Presence of N2-(deoxyguanosin-8-yl)-2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues
7. The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
8. Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods
9. The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods
10. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
11. Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats
12. Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay
13. Synthesis and anti lipid-peroxidation activity of hydroquinone monoalky1 ethers
14. Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced 2-amino-6-methyldipyrido[1,2-a:3′,2′-d] imidazole (Glu-P-1)
15. Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats
16. Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1)-induced inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
17. Prevention by synthetic phenolic antioxidants of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis and prevention of carcinogenesis
18. Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in paraffinembedded sections and tissue distribution
19. Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis
20. IPAP: Image processor for analytical pathology
21. Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: Results of extended and combination treatment experiments
22. Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates
23. DNA adducts of heterocyclic amine food mutagens: Implications for mutagenesis and carcinogenesis
24. Role of ethenol DNA adducts in carcinogenesis induced by vinyl chloride in rats
25. Relationship of DNA adducts derived from 2-acetylaminofluorene to cell proliferation and the induction of rodent liver and bladder tumors
26. Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects
27. Dose-response relationships in chemical carcinogenesis: From DNA adducts to tumor incidence
28. Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: Relationship of DNA binding to initiation of skin carcinogenesis
29. DNA adducts in target and nontarget tissues of 3,2′-dimethyl-4-aminobiphenyl in rats
30. Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2′-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation
31. Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3′,2′-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone
32. Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats
33. Mechanism of oxidative DNA damage induced by a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
34. Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro
35. Modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) of 3,2′-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis
36. Carcinogenicity of 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the rat