Organ variation in the mutagenicity of MeIQ in Big Blue® lacI transgenic mice

Mutation Research - Genetic Toxicology

Volumn 369, Issue 1, 1996, Pages 45-49

  Suzuki, Takayoshi ^a   Hayashi, Makoto ^a   Ochiai, Masako ^b   Wakabayashi, Keiji ^b   Ushijima, Toshikazu ^b   Sugimura, Takashi ^b   Nagao, Minako ^b   Sofuni, Toshio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Big Blue mice; Colon; MeIQ; Micronucleus; Mutant frequency

Indexed keywords

2 AMINO 3,4 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; HETEROCYCLIC AMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; COLON; CONTROLLED STUDY; FEMALE; FORESTOMACH; GENOTOXICITY; HEART; LIVER; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; TYPHIMURIUM;

EID: 0029902154     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90046-4     Document Type: Article

References (14)

1. Butterworth, B.E., J.A. Popp, R.B. Conolly and T.L. Goldsworthy (1992) Chemically induced cell proliferation in carcinogenesis In: H. Vainio, P. Magee, D. McGregor and A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification, IARC, Lyon, IARC Scientific Pub. No. 116 pp. 279-305.
2. CSGMT (Collaborative Study Group for the Micronucleus Tests) (1993) Evaluation of mouse micronucleus assay to screen carcinogens, MMS Commun., Suppl., 1, 1-32.
3. Hayashi, M., T. Morita, Y. Kodama, T. Sofuni and M. Ishidate, Jr. (1990) The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides, Mutation Res., 245, 245-249.
4. Kohler, S.W., G.S. Provost, A. Fieck, P.L. Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman and J.M. Short (1991) Spectra of spontaneous and mutagen-induced mutations in the lacl gene in transgenic mice, Proc. Natl. Acad. Sci. USA, 88, 7958-7962.
5. Kunz, V.J., U. Keim and L. Fuhrmann (1972) Die Proliferation von Muskelzelen und Bindegewebszellen des Rattenherzens wahrend des postnatalen Wachstums, Exp. Pathol., 6, S.270-277.
6. Layton, D.W., K.T. Bogen, M.G. Knize, F.T. Hatch, V.M. Johnson and J.S. Felton (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research, Carcinogenesis, 16, 39-52.
7. Lee, A.T., C. DeSimone, A. Cerami and R. Bucala (1994) Comparative analysis of DNA mutations in lad transgenic mice with age, FASEB J., 8, 545-550.
8. Ohgaki, H., S. Takayama and T. Sugimura (1991) Carcinogenicities of heterocyclic amines in cooked food, Mutation Res., 259, 399-410.
9. Ono, T., Y. Miyamura, H. Ikehata, H. Yamanaka, A. Kurishita, K. Yamamoto, T. Suzuki, T. Nohmi, M. Hayashi and T. Sofuni (1995) Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age, Mutation Res., 338, 183-188.
10. Rogers, B.J., G.S. Provost, R.R. Young, D.L. Putman and J.M. Short (1995) Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay (I), Mutation Res., 327, 57-66.
11. Sugimura, T., K. Wakabayashi, M. Nagao and H. Ohgaki (1989) Heterocyclic amines in cooked food, In: S.L. Taylor and R.A. Scanlan (Eds.) Food Toxicology: A Perspective on the Relative Risks, Marcel Dekker, New York and Basel, pp. 31-55.
12. Thompson, L.H., J.D. Tucker, S.A. Stewart, M.L. Christensen, E.P. Salazar, A.V. Carrano and J.S. Felton (1987) Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity, Mutagenesis, 2, 483-487.
13. Ushijima, T., Y. Hosoya, M. Ochiai, H. Kusida, K. Wakabayashi, T. Suzuki, M. Hayashi, T. Sofuni, T. Sugimura and M. Nagao (1994) Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice, Carcinogenesis, 15, 2805-2809.
14. Zhang, X.B., J. Felton, J.D. Tucker and J.A. Heddle (1995) The mutagenicity of food mutagens in the intestine (abstract), Environ. Mol. Mutagen. 25 (Suppl. 25), 60.